摘要
目的:观察山泽参黄汤治疗2型糖尿病合并非酒精性脂肪性肝病的临床疗效。方法:90例2型糖尿病合并非酒精性脂肪性肝病患者,按照随机数字表法随机分为对照组和观察组各45例。对照组患者给予吡格列酮,观察组患者给予山泽参黄汤。治疗3个月后,比较两组患者的临床疗效、肥胖程度、糖脂代谢水平、肝功能水平以及不良反应发生情况。结果:①观察组有效率(91.11%)明显高于对照组有效率(73.33%),差异有统计学意义(P<0.05)。②观察组患者体质量指数、腰/臀比明显低于对照组患者,肝/脾CT值显著高于对照组患者,差异均有统计学意义(P<0.05)。③观察组患者空腹血糖、餐后2小时血糖、血清胰岛素、胰岛素抵抗指数以及胰岛β细胞的分泌指数均明显优于对照组患者,差异有统计学意义(P<0.05)。④观察组的血清总胆固醇、三酰甘油以及低密度脂蛋白胆固醇水平均低于对照组,高密度脂蛋白胆固醇水平显著高于对照组,差异有统计学差异(P<0.05)。⑤治疗后,观察组血清谷丙转氨酶、谷草转氨酶、谷氨酰转肽酶水平均明显低于对照组患者,差异有统计学意义(P<0.05)。⑥两组患者干预治疗期间均未见严重不良反应事件发生。结论:山泽参黄汤治疗2型糖尿病合并非酒精性脂肪性肝病临床疗效显著,能够有效减轻患者肝脏脂肪堆积,改善胰岛素抵抗,保护胰岛功能,并有效调节血糖,恢复患者肝功能。
Objective:To observe the clinical efficacy of Shanze Shenhuang Decoction in treatment of type 2 diabetes combined with non-alcoholic fatty liver disease.Methods:90 patients with type 2 diabetes and non-alcoholic fatty liver disease were randomly divided into a control group and an observation group of 45 cases according to the random number table method.Patients in the control group were given pioglitazone,and patients in the observation group were given Shanze Shenhuang Decoction.After 3 months of treatment,the clinical efficacy,obesity,glucose and lipid metabolism level,liver function level and adverse reactions were compared between the two groups.Results:①The effective rate of the observation group(91.11%)was significantly higher than that of the control group(73.33%),the difference was statistically significant(P<0.05).②The body mass index(BMI)and waist-hip ratio(WHR)of the observation group were significantly lower than those of the control group,and the CT values of the liver/spleen were significantly higher than those of the control group(P<0.05).③Fasting blood glucose(FBG),plasma glucose 2 hours after glucose load(2hPG),fasting insulin(FINS),insulin resistance index(HOMA-IR)and islets in the observation group Theβ-cell secretion index(HOMA-β)was significantly better than that of the control group,the difference was statistically significant(P<0.05).④The levels of total cholesterol(TC),triglycerid(TG)and low-density lipoprotein cholesterol(LDL-C)in the observation group were lower than those in the control group,and high-density lipoprotein The level of high-density lipoprotein cholesterol(HDL-C)was significantly higher than that of the control group,the difference was statistically significant(P<0.05).⑤After treatment,the levels of serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),and gamma-glutamyl transferase(GGT)in the observation group were significantly lower than those in the control group,the difference It is statistically significant(P<0.05).⑥No serious adverse events occurred during the intervention of the two groups of patients.Conclusion:Shanze Shenhuang Decoction is effective in the treatment of type 2 diabetes with non-alcoholic fatty liver disease.It can effectively reduce the accumulation of liver fat in patients,improve insulin resistance,protect islet function,effectively regulate blood sugar,and restore liver function.
作者
丁冬生
段寅慧
朱海燕
郦凌燕
DING Dongsheng;DUAN Yinhui;ZHU Haiyan;LI Lingyan(Danyang Chinese Medicine Hospital,Danyang Jiangsu China 212300)
出处
《中医学报》
CAS
2020年第10期2246-2251,共6页
Acta Chinese Medicine
基金
江苏省丹阳市科技局社会发展项目(SF201704)。
关键词
2型糖尿病
非酒精性脂肪性肝病
山泽参黄汤
type 2 diabetes
non-alcoholic fatty liver disease
Shanze Shenhuang Decoction
