摘要
梳理学科领域主题的发展动态与研究脉络,揭示学科领域的主题演化规律与特征,对学科的发展具有重要意义。以生命周期理论为基础,以主题词为表征,从网络结构演变特征和主题内容演变角度,对肺癌靶向药物领域不同生命周期阶段进行主题演化分析,全面深入揭示该领域发展的特征和规律。结果表明,在共词网络结构演变中,网络整体随阶段不同存在差异;在主题内容演变方面,研究主题主要体现出持续型、新生型、分化型、弱化型四种形式,靶向药物联合传统治疗方法是肺癌的主要治疗方案,治疗方案及治疗效果将持续成为研究热点,靶向药物的耐药性及耐药机制、新一代靶向药物的应用和免疫治疗的研究在后期受关注程度升高、研究地位上升,将成为有发展潜力的研究主题。
It is of great significance for the development of disciplines to sort out the development trends and research veins of subjects and reveal the evolution laws and characteristics of subjects in the field of disciplines.Based on life cycle theory and subject words,this paper analyzed the theme evolution in different life cycle stages of lung cancer targeting drug field from the perspective of network structure evolution characteristics and subject content evolution,and revealed the characteristics and rules of development in this field in an all-round and in-depth way.The experimental results in the field of lung cancer targeting drugs show that in the evolution of the Co-word network structure,the whole network varies with different stages;in the evolution of the subject content,the research topics mainly embody the four forms of"persistent","new","weakened"and"differentiated".Targeted drugs combined with traditional therapies are the main therapies for lung cancer.Therapeutic schemes and therapeutic effects will continue to be a research hotspot.Drug resistance and drug resistance mechanism of targeted drugs,application of new generation of targeted drugs and research status of immunotherapy will rise in the later stage,which will have potential for development.Research topics.
作者
吴胜男
卫慧蓉
于琦
邰杨芳
贺培凤
Wu Shengnan;Wei Huirong;Yu Qi;Tai Yangfang;He Peifeng(School of Management,Shanxi Medical University,Taiyuan,030001;School of Humanities and Social Sciences,Shanxi Medical University,Taiyuan 030001,China)
出处
《信息资源管理学报》
CSSCI
2020年第5期112-121,共10页
Journal of Information Resources Management
基金
国家自然科学基金项目:“多维视角下基于文献实体单元共现网络分析的药物关系知识发现研究”(71804102)
国家自然科学基金项目:“基于多元分析的科研文献微观实体评价理论与实证研究——以生物医学为例”(71573162)
山西省高等医学哲学社会科学研究项目:“面向知识挖掘的药物实体共现网络的多维分析”(2019W040)。
关键词
学科领域
主题演化
网络结构
生命周期
靶向药物
Subject area
Subject evolution
Network structure
Life cycle
Targeted drugs
