摘要
以四氧化三铁(Fe3O4)纳米粒子为支撑材料,模板选用芒柄花黄素,温敏功能单体和辅助功能单体分别选用N-异丙基丙烯酰胺(NIPAM)和甲基丙烯酸(MAA),制备出磁性和温度双响应型分子印迹材料(MTMIPs),并结合高效液相色谱法(HPLC)将其用于红车轴草中芒柄花黄素的定向萃取研究。利用扫描电镜(SEM)、透射电镜(TEM)、红外光谱(FT-IR)、热重分析(TGA)、磁性分析(VSM)等手段对MTMIPs进行表征,随后对其温敏及吸附性能进行考察。结果表明,MTMIPs为核壳型结构,热稳定性好,具有良好的吸附性能(16.43 mg/g)和温敏特性,对芒柄花黄素的吸附动力学符合准二级动力学模型,吸附过程符合Langmuir单分子层吸附。HPLC检测结果显示MTMIPs可用于从复杂样品中分离富集芒柄花黄素。
The magnetic and temperature double response molecularly imprinted polymers for formononetinspecific adsorption(MTMIPs) were successfully prepared by using Fe3 O4 as supporting matrix, formononetin as template, N-isopropyl acrylamide as the thermo-sensitive type functional monomer and methacrylic acid as auxiliary functional monomer. SEM, TEM, FT-IR, TGA and magnetic analysis were used to characterize the structure of MTMIPs, and then their adsorption properties and reproducibility were investigated. The results showed that MTMIPs was a core-shell structure with good thermal stability, good adsorption performance(16.43 mg/g) and fast adsorption performance. The adsorption kinetics of formononetin was consistent with the quasi-second-order kinetics model, and the adsorption process was consistent with the Langmuir monolayer adsorption with good reproducibility. HPLC test results show that MTMIPs can be used to separate and enrich formononetin from complex samples.
作者
何家垣
蒋壮飞
马蓉蓉
杨莉莉
李清瑶
谭玲
陈志涛
张起辉
HE Jiayuan;JIANG Zhuangfei;MA Rongrong;YANG Lili;LI Qingyao;TAN Ling;CHEN Zhitao;ZHANG Qihui(School of Chemistry and Chemical Engineering,Chongqing University,Chongqing 400044,China;School of Pharmacy,Chongqing University,Chongqing 400044,China)
出处
《化工学报》
EI
CAS
CSCD
北大核心
2020年第10期4711-4719,共9页
CIESC Journal
基金
国家自然科学基金项目(819734512)
医工联合项目(2019CDYGYB027)
2019技术预见与制度创新项目(cstc2019jsyjyzysbAX00204)
重庆市科委项目(cstc2018jcyjAX06615)
重庆市教育委员会科学技术研究项目(KJZD-K2018001036)
重庆市研究生创新基金项目(CYS180337)
中央高校基本科研业务费(2019CDXYHG00131)。
关键词
磁性温敏材料
分子印迹材料
聚合物
吸附剂
纳米材料
magnetic temperature-sensitive materials
molecular imprinted materials
polymers
adsorbents
nanomaterials
