摘要
目的观察皮瓣修复结合光动力疗法在面部皮肤癌治疗中的应用效果。方法抽取2015年7月至2019年1月河南科技大学第二附属医院收治的面部皮肤癌患者86例,其中采用皮瓣修复联合光动力治疗的43例患者作为研究组,采用皮瓣修复治疗的43例患者作为对照组。对比两组患者治疗6个月后的临床疗效,治疗12个月后的外观满意度,治疗前、治疗12个月后生存质量[即欧洲癌症治疗研究组织(EORTC)的生命质量测定量表(QLQ-C30)]评分,并记录两组不良反应及治疗12个月后的复发情况。结果治疗6个月后,研究组治疗总有效率为93.02%(40/43),高于对照组的76.77%(33/43),P<0.05。治疗12个月后,研究组患者外观满意率为95.35%(41/43),高于对照组的79.07%(34/43),P<0.05。治疗12个月后,两组患者EORTC QLQ-C30各项评分均优于治疗前,且研究组评分优于对照组(P<0.05)。治疗后,研究组不良反应发生率(4.65%,2/43)低于对照组(18.60%,8/43),P<0.05;治疗12个月后,两组复发率比较差异未见统计学意义(P>0.05)。结论对于面部皮肤癌患者,皮瓣修复结合光动力疗法可显著改善患者面部外观满意度,提升患者生存质量,且不良反应少。
Objective To observe the efficacy of skin flap repair combined with photodynamic therapy in the treatment of facial skin cancer.Methods A total of 86 patients with facial skin cancer hospitalized in the Second Affiliated Hospital of Henan University of Science and Technology from July 2015 to January 2019 were selected.Among them,43 patients were treated by flap repair combined with photodynamic therapy as the study group,and 43 patients were treated by flap repair as the control group.The clinical efficacy after 6 months of treatment,appearance satisfaction after 12 months of treatment,and quality of life assessed by Quality of Life Questionnare-Core 30(QLQ-C30)of the European Organization for Research and Treatment of Cancer(EORTC)before treatment and after 12 months of treatment were compared between the two groups.The adverse reactions and recurrence after 12 months of treatment of the two groups were recorded.Results After 6 months of treatment,the total effective rate in study group was 93.02%(40/43),higher than the 76.77%(33/43)in control group,P<0.05.After 12 months of treatment,the appearance satisfaction rate in study group was 95.35%(41/43),which was higher than the 79.07%(34/43)in control group,P<0.05.After 12 months of treatment,the scores of each item of EORTC QLQ-C30 in the two groups were better,compared with those before treatment(P<0.05);and the scores in study group were better than those in control group(P<0.05).After treatment,the adverse reaction rate in study group(4.65%,2/43)was significantly lower than that in control group(18.60%,8/43),P<0.05,and there was no difference in the recurrence rate between the two groups after 12 months of treatment(P>0.05).Conclusions For patients with facial skin cancer,skin flap repair combined with photodynamic therapy has can improve the facial appearance satisfaction,and enhance the quality of life,with few adverse reactions.
作者
师军涛
徐淑江
李劲涛
Shi Juntao;Xu Shujiang;Li Jintao(Department of Plastic Surgery,the Second Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,China)
出处
《中国实用医刊》
2020年第17期59-62,共4页
Chinese Journal of Practical Medicine
关键词
面部皮肤癌
皮瓣修复
光动力
疗效
Facial skin cancer
Skin flap repair
Photodynamics
Efficacy
