摘要
核受体过氧化物酶体增殖物激活受体γ(PPARγ)通过调控相关基因表达而增强胰岛素敏感性,促进脂肪细胞分化和脂肪形成,具有抗动脉粥样硬化、抗炎、抗氧化等特性。人类PPARγ基因(PPARG)含有数以千计的变异位点,其中位于外显子区的rs1801282和rs3856806,启动子区的rs10865710和rs7649970四个位点被广泛报道与冠心病(CHD)显著相关。在关联机制上,PPARG基因变异主要通过引起血脂紊乱、升高血压、增加体脂含量、促进胰岛素抵抗等机制而增加CHD的风险。本文就PPARG基因多态性与CHD的相关性及关联机制作一综述。
By regulating the expression of related genes,nuclear receptor peroxisome proliferator-activated receptor gamma(PPARγ)enhances insulin sensitivity,promotes adipocyte differentiation,and promotes adipogenesis.PPARγhas the characteristics of anti-atherosclerosis,anti-inflammation,and anti-oxidation.Human PPARγgene(PPARG)contains thousands of polymorphic loci,among them two polymorphisms(rs1801282 and rs3856806)in the exon regions and two polymorphisms(rs10865710 and rs7649970)in the promoter regions were widely reported to be significantly associated with coronary heart disease(CHD).In mechanisms,the polymorphisms in PPARG increase the risk of CHD mainly by causing dyslipidemia,elevating blood pressure,increasing body fat content,and promoting insulin resistance.This review concentrates on the relationships between the polymorphisms in PPARG and CHD,as well as the underlying mechanisms.
作者
曾慧润
张涛
宋永砚
ZENG Huirun;ZHANG Tao;SONG Yongyan(Department of Clinical Medicine,North Sichuan Medical College,Nanchong,Sichuan,637000,China;School of Preclinical Medicine,and Nanchong Key Laboratory of Metabolic Drugs and Biological Products,North Sichuan Medical College)
出处
《临床心血管病杂志》
CAS
北大核心
2020年第8期773-776,共4页
Journal of Clinical Cardiology
基金
四川省教育厅重点项目(No:17ZA0172)
南充市校合作科研专项(No:NSMC2070403)。
关键词
过氧化物酶体增殖物激活受体Γ
PPARG
多态性
冠心病
血脂
peroxisome proliferator-activated receptor gamma
PPARG
polymorphism
coronary heart disease
blood lipids
