摘要
以邻苯二胺和一氯乙酸为反应物,盐酸为催化剂,用常规加热和微波辐射合成了2-氯甲基苯并咪唑,考察了微波辐射时间、微波输出功率、物料比对产率的影响。结果表明,微波辐射方式较常规加热缩短了反应时间,提高了反应速率和产率,且微波辐射较佳工艺条件为:输出功率为700 W、间歇辐射时间10 min、n(邻苯二胺)∶n(一氯乙酸)=1∶1.14时,目标产物的合成收率可达66.9%。
2-Chloromethyl Benzimidazole was synthesized by conventional heating and microwave irradiation in the presence of o-phenylenediamine with chloroacetic acid,using hydrochloric acid as catalyst.The effects of microwave irradiation time,microwave output power and material ratio on the yield were investigated.The experimental results show that microwave radiation shortens the reaction time and increases the reaction rate and yield,the optimum microwave irradiation conditions are:the output power is 700 W,the intermittent irradiation time is 10 min,n(o-phenylenediamine)∶n(chloroacetic acid)was 1∶1.14,and the yield of the target product is 66.9%.
作者
鲍娟
陈小芳
张精安
Bao Juan;Chen Xiaofang;Zhang Jing’an(College of Medical Technology, Guangdong Medical University, Dongguan 523808, Guangdong, China;College of Pharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, Guangdong, China)
出处
《精细石油化工》
CAS
北大核心
2020年第5期16-18,共3页
Speciality Petrochemicals
基金
广东医科大学科研基金面上培育项目(M2017034)
广东省卫生厅课题(A2016289)。
关键词
微波辐射
2-氯甲基苯并咪唑
合成
microwave radiation
2-chloromethyl benzimidazole
synthesis
