摘要
目的:探讨福建龙岩地区居民甲状腺疾病与尿碘含量的相关性,为龙岩地区甲状腺疾病患者提供科学补碘依据。方法:选在2017年1月-2019年3月龙岩市第二医院内分泌科门诊及住院就诊的甲状腺疾病患者643例(Graves病组155例,甲状腺结节组379例,慢性淋巴细胞性甲状腺炎组109例),并选取同期在笔者所在医院体检中心体检的龙岩地区无甲状腺疾病的健康人群805例为对照组。结果:Graves病组、甲状腺结节组、慢性淋巴细胞性甲状腺炎组和对照组尿碘中位数分别为336.45、265.65、351.39、198.65 μg/L,组间尿碘中位数比较差异有统计学意义(H=20.15,P<0.05)。Graves病组与慢性淋巴细胞性甲状腺炎组尿碘中位数均显著高于对照组(Z=5.489、6.368,P<0.05);慢性淋巴细胞性甲状腺炎组和甲状腺结节组比较差异有统计学意义(Z=3.953,P<0.05)。Graves病组血清游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)、甲状腺过氧化物酶抗体(TPOAB)、甲状腺球蛋白抗体(TGAB)与对照组比较差异有统计学意义(P<0.05);甲状腺结节组、慢性淋巴细胞性甲状腺炎组TPOAB、TGAB与对照组比较差异有统计学意义(P<0.05);Graves病组、甲状腺结节组、慢性淋巴细胞性甲状腺炎组、对照组的尿碘含量与血清游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)、甲状腺过氧化物酶抗体(TPOAB)、甲状腺球蛋白抗体(TGAB)间均无相关性(P>0.05)。结论:根据健康人群尿碘含量,龙岩地区属于碘适量地区。龙岩地区居民尿碘含量与甲状腺功能无明显相关性。
Objective:To explore the correlation between thyroid diseases and urinary iodine content in Longyan area of Fujian province,and to provide scientific basis for iodine supplementation for patients with thyroid diseases in Longyan area.Method:Selected 643 patients with thyroid diseases from January 2017 to March 2019 in the Department of Endocrinology,the Second Hospital of Longyan City (55 cases in Graves disease group,379 cases in thyroid nodule group and 109 cases in chronic lymphocytic thyroiditis group).A total of 805 healthy people without thyroid disease in Longyan area who underwent physical examination at the same time in that hospital were selected as the control group.Result:Median urinary iodine in Graves disease group,thyroid nodule group,chronic lymphocytic thyroiditis group and control group were 336.45,265.65,351.39,198.65 μg/L.There were significant differences in the median urinary iodine among groups (H=20.15,P<0.05).The median urinary iodine in Graves’ disease group and chronic lymphocytic thyroiditis group was significantly higher than that in control group (Z=5.489,6.368,P<0.05).There was significant difference between chronic lymphocytic thyroiditis group and thyroid nodule group (Z=3.953,P<0.05).There were significant differences in serum free triiodothyronine (FT3),free thyroxine (FT4),thyroid stimulating hormone (TSH),thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TGAb) between Graves disease group and control group (P<0.05).TPOAb and TGAb in thyroid nodule group and chronic lymphocytic thyroiditis group were significantly different from those in control group (P<0.05).There was no correlation between urinary iodine content and serum free triiodothyronine (FT3),free thyroxine (FT4),thyroid stimulating hormone (TSH),thyroid peroxidase antibody (TPOAb),thyroglobulin antibody (TGAb) in Graves disease group,thyroid nodule group,chronic lymphocytic thyroiditis group and control group (P>0.05).Conclusion:According to the urine iodine content of healthy people,Longyan area belongs to the iodine moderate area.There was no significant correlation between urinary iodine content and thyroid function in Longyan area.
作者
钟方
郑文通
游育东
陈祥
阙敢波
廖德泳
彭明健
连铃
ZHONG Fang;ZHENG Wentong;YOU Yudong;CHEN Xiang;QUE Ganbo;LIAO Deyong;PENG Mingjian;LIAN Ling(Second Hospital of Longyan City,Longyan 364000,China)
出处
《中外医学研究》
2020年第27期166-168,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
基金
龙岩市科技计划项目(2017LY54)。
关键词
尿碘
甲状腺疾病
甲状腺功能
甲状腺结节
Urine iodine
Thyroid diseases
Thyroid function
Thyroid nodules
