摘要
目的探讨非小细胞肺癌(NSCLC)患者血清趋化因子CCL-20、胸苷激酶(TK1)与根治性手术后早期复发、转移的关系。方法选取实施肺癌根治性手术的NSCLC患者109例,根据随访2年内患者出现复发或者转移情况分为复发组50例、未复发或转移的患者(对照组)59例。对比2组术前、术后1个月、术后3个月血清CCL-20、TK1水平,并采用Logistic多因素分析法分析血清CCL-20、TK1水平与NSCLC术后复发转移的关系。结果复发组和对照组在术前的血清CCL-20、TK1水平差异无统计学意义(P>0.05),复发组术后1个月、3个月的血清CCL-20、TK1水平高于对照组(P<0.05)。TNM分期增加、低分化、术前发生淋巴结转移、术后3个月的CCL-20、TK1水平增高、术后未行辅助性化疗是NSCLC患者术后复发或转移的独立危险因素(P<0.05)。结论检测NSCLC患者术后CCL-20、TK1水平对于评估患者术后复发、转移具有一定的价值。
Objective The relationship between serum chemokine CCL-20,thymidine kinase(TK1)and early recurrence and metastasis after radical surgery in patients with non-small cell lung cancer(NSCLC).Methods 109 patients with NSCLC who underwent radical surgery for lung cancer were selected.According to the recurrence or metastasis within 2 years of follow-up,50 patients with recurrence and 50 patients without recurrence or metastasis were selected as the control group.Serum CCL-20 and TK1 levels were compared before operation,1 month after operation and 3 months after operation.Logistic multivariate analysis was used to analyze the relationship between serum CCL-20 and TK1 levels and recurrence and metastasis after NSCLC.Results There were no significant differences in serum CCL-20 and TK1 levels between the recurrent and control groups(P>0.05).The serum CCL-20 and TK1 levels in the recurrent group were higher than those in the control group at 1 month and 3 months after operation.(P<0.05);the proportion of stageⅢpatients with TNM stage,poorly differentiated tumor differentiation,lymph node metastasis,and postoperative chemotherapy were lower in the recurrent group than in the control group,and the difference was statistically significant(P<0.05);increased TNM staging,poor differentiation,preoperative lymph node metastasis,increased CCL-20,TK1 levels at 3 months postoperatively,and no adjuvant chemotherapy after surgery were independent risk factors for recurrence or metastasis in patients with NSCLC(P<0.05).Conclusion The detection of postoperative CCL-20 and TK1 levels in patients with NSCLC has certain value in evaluating patients with recurrence and metastasis.
作者
焦江琴
JIAO Jiangqin(Second Affiliated Hospital of Henan University of Science and Technology,Luoyang,471000)
出处
《实用癌症杂志》
2020年第10期1635-1638,共4页
The Practical Journal of Cancer
