摘要
目的探讨右美托咪啶对胃癌手术患者麻醉应激反应的抑制作用。方法分析2017年2月到2019年2月乐山市人民医院收治的116例胃癌手术患者的临床资料,随机分为对照组和观察组,对照组患者给予常规麻醉,观察组患者在对照组麻醉基础上给予右美托咪啶,统计2组患者手术过程中体征指标BIS、SpO 2、MAP、HR,分析右美托咪定对胃癌麻醉手术患者应激反应的抑制效果。结果2组患者BIS值于T2、T3时刻比较差异有统计学意义(P<0.05),T0、T1时刻比较差异无统计学意义(P>0.05)。2组患者SpO 2、MAP、HR三项指标T0时刻比较差异无统计学意义(P>0.05);观察组手术中三项指标变化幅度低于对照组,且2组患者T1、T2、T3时刻比较差异有统计学意义(P<0.05)。结论在常规麻醉基础上联合右美托咪啶麻醉对胃癌手术患者效果更好,较常规麻醉治疗在降低机体刺激、抑制应激反应发生方面效果更显著,临床值得推广。
Objective To investigate the inhibitory effect of dexmedetomidine on anesthetic stress response in patients with gastric cancer.Methods The clinical data of 116 patients with gastric cancer were analyzed and randomly divided into the control group and the observation group.Patients in the control group were given routine anesthesia.The patients in the control group were based on the anesthesia of the control group.Metopidine was used to analyze the signs of BIS,SpO 2,MAP and HR during the operation of the two groups.The inhibitory effect of dexmedetomidine on the stress response in patients with gastric cancer anesthesia was analyzed.Results The BIS values of the two groups were significantly different at T2 and T3(P<0.05).There was no significant difference between T0 and T1(P>0.05).The three indicators of SpO 2,MAP and HR were T0.There was no significant difference in the difference(P>0.05).The change of the three indexes in the operation was lower than that in the control group,and the difference between T1,T2 and T3 was statistically significant(P<0.05).Conclusion The clinical effect of dexmedetomidine anesthesia in patients with clinical gastric cancer is better.It is more effective than conventional anesthesia in reducing body irritation and inhibiting the occurrence of stress reaction.It is worthy of promotion.
作者
杨继梅
卢文江
胡捷斯
YANG Jimei;LU Wenjiang;HU Jiesi(Leshan People's Hospital,Leshan,614000)
出处
《实用癌症杂志》
2020年第10期1693-1695,1734,共4页
The Practical Journal of Cancer
基金
2017年四川省卫生和计划生育委员会科研课题(普及应用项目)(编号:17PJ123)。
关键词
右美托咪啶
胃癌手术
麻醉应激反应
Dexmedetomidine
Gastric cancer surgery
Anesthetic stress response
