摘要
目的:探讨阿司匹林、替格瑞洛联合治疗不稳定型心绞痛的治疗效果及对不良反应的影响。方法:回顾性分析笔者所在医院2017年10月-2018年12月收治的94例不稳定型心绞痛患者的临床资料,按照治疗方式的不同将其分为试验组和对照组,每组47例。试验组采用阿司匹林、替格瑞洛联合治疗,对照组采用阿司匹林联合氯吡格雷治疗。比较两组治疗效果、心绞痛发作次数和发作持续时间、血清炎性因子水平及不良反应发生率。结果:试验组治疗总有效率高于对照组,心绞痛发作次数和发作持续时间均优于对照组,血清炎性因子水平显著低于对照组,差异均有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:采用阿司匹林、替格瑞洛联合治疗不稳定型心绞痛的效果显著,可改善患者的临床症状,缩短发作时间,降低炎性因子水平,保证安全性,值得推广。
Objective:To investigate the treatment effect of Aspirin combined with Ticagrelor on unstable angina pectoris and its effect on adverse reactions.Method:The clinical data of 94 patients with unstable angina pectoris admitted in our hospital from October 2017 to December 2018 were retrospectively analyzed.According to different treatment methods,the patients were divided into the experimental group and the control group,with 47 patients in each group.The experimental group was treated with Aspirin combined with Ticagrelor,while the control group was treated with Aspirin combined with Clopidogrel.The treatment effect,the number and duration of angina attacks,the serum inflammatory factors level and the incidence of adverse reactions were compared between the two groups.Result:The total effective rate of treatment in the experimental group was higher than that in the control group,the number and duration of angina attacks were better than those in the control group,and the level of serum inflammatory factors was significantly lower than that in the control group,the differences were statistically significant (P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05).Conclusion:The combination of Aspirin and Ticagrelor in the treatment of unstable angina pectoris has a significant effect,which can improve the clinical symptoms of patients,shorten the onset time,reduce the level of inflammatory factors,and ensure the safety,which is worthy of promotion.
作者
谢志艺
XIE Zhiyi(Zhangzhou Hospital Affiliated to Fujian Medical University,Zhangzhou 363000,China)
出处
《中外医学研究》
2020年第25期149-151,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
