摘要
目的探讨六磨汤加味灌肠对晚期肿瘤性肠梗阻患者生命质量的影响。方法选取2018年3月至2019年3月绵阳市中心医院收治的晚期肿瘤性肠梗阻患者78例作为研究对象,按照随机数字表法分为对照组与观察组,各39例。对照组采用常规治疗,观察组在对照组基础上采用六磨汤加味灌肠治疗。比较两组临床疗效、中医证候积分、胃动素(MLT)、血管活性肠肽(VIP)水平、生命质量[卡氏评分(KPS评分)]、肛门排气及恶心呕吐、腹痛腹胀缓解时间。结果观察组治疗有效率87.18%高于对照组64.10%(P<0.05);治疗2周后观察组中医证候积分低于对照组,KPS评分高于对照组(P<0.05);观察组肛门排气及恶心呕吐、腹痛腹胀症状缓解时间短于对照组(P<0.05);治疗2周后观察组MLT水平高于对照组,VIP水平低于对照组(P<0.05)。结论六磨汤加味灌肠治疗晚期肿瘤性肠梗阻疗效显著,能降低中医证候积分,缩短症状缓解时间,调节血清MLT、VIP水平,改善生命质量。
Objective To explore the effect of modified Liumo Decoction and fenema on advanced tumor intestinal obstruction.Methods A total of seventy-eight patients with advanced tumor intestinal obstruction admitted to Mianyang Central Hospital from March 2018 to March 2019 were selected as the research object.According to the random number table method,they were divided into a control group and an observation group,with 39 cases in each group.The control group was treated with conventional treatment,and the observation group was treated with Liumo Decoction and modified enema on the bases of the control group.Clinical efficacy,traditional Chinese medicine syndrome scores,plasma motilin(MLT),vasoactive intestinal peptide(VIP)levels,quality of life[Kalvin score(KPS score)],time to relieve anal exhaust,nausea and vomiting,abdominal pain and bloating were compared.Results The total effective rate in the observation group was 87.18%higher than that in the control group(P<0.05).After 2 weeks of treatment,the TCM syndrome score in the observation group was lower than that in the control group,and the KPS score was higher than that in the control group(P<0.05).The relief time of anal exhaust,nausea and vomiting,and abdominal pain in the observation group was shorter than that in the control group(P<0.05).After 2 weeks of treatment,the MLT level in the observation group was higher than that in the control group,and the VIP level was lower than that in the control group(P<0.05).Conclusion Modifed Liumo Decoction combined with enema is effective in the treatment of advanced tumor intestinal obstruction.It can reduce the TCM syndrome score,shorten the symptom relief time,adjust the plasma MLT and VIP levels,and improve the quality of life.
作者
冯勇
谭冬梅
李彬
蒲静
王娟
FENG Yong;TAN Dong-Mei;LI Bin;PU Jing;WANG Juan(Department of Integrated Traditional Chinese and Western Medicine,Mianyang Central Hospital,Mianyang 621000,China)
出处
《中国药物经济学》
2020年第8期122-124,128,共4页
China Journal of Pharmaceutical Economics
关键词
六磨汤加味
灌肠
晚期
肿瘤性肠梗阻
中医证候积分
症状缓解时间
生命质量
Modifed Liumo decoction
Enema
Advanced tumor intestinal obstruction
TCM syndrome score
Symptom relief time
Quality of life
