摘要
本文研究了８名健康志愿者静脉滴注８０ｍｇ奥美拉唑药代动力学和临床药效学。方法：血药浓度测定采用ＨＰＬＣ方法，２４ｈ胃内ｐＨ监测采用Ｄｉｇｉｔｒａｐｐｅｒ ＭＫ Ⅲ动态 ｐＨ监测仪。结果：奥美拉唑药－时曲线符合二室开放模型， ８名受试者 ２４ ｈ基础胃酸ｐＨ平均为 ２．３０±０．７４， ｐＨ＞ ４总时间百分比为１６．６７％ ±１１．９７％；静脉滴注 ８０ｍｇ奥美拉唑后， ２４ ｈ胃内 ｐＨ平均值和 ｐＨ＞ ４总时间百分比分别升至５．５７±０．９３和８１．０７％±１５．７５％（Ｐ＜０．０１）。结论：结果表明静脉滴注８０ｍｇ奥美拉唑可显著抑制胃酸分泌，但血药浓度与抑酸作用程度不相关。
OBJECTIVE: The pharmacokinetics and clinical pharmacodynamics of omeprazole after an infusion dose of 80mg were studied in 8 healthy subjects. METHODS. Plasma concentrations of omeprazole were determined by HPLC method, and 24-hour intragastric pH monitoring was carried out in each subject by means of Digitrapper MK Ⅲ ambulatory pH monitor RESULTS: Plasma concentration-time curve was fitted to a twocompartment open pharmacokinetic model. In basic gastric secretion test, 24-hour mean intragastric pH was 2.30 ±0.74 and the total percentage time of intragastric pH>4 was (16.67 ±11 .97)%. After infusion of 80mg omeprazole, 24-hour mean intragastric pH and the total percentage time of intragastric pH>4 increased to 5.57 ±0.93 and (81 .07 ± 15.75)% respectively(p<0.01 ). CONCLUSION: The results showed that omeprazole has great inhibitory effect on gastric acid secretion, No significant correlation was found between the plasma concentration and the degree of acid inhibition.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2000年第4期286-288,共3页
The Chinese Journal of Clinical Pharmacology
