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Mitochondria as a target for neuroprotection: role of methylene blue and photobiomodulation 被引量:6

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摘要 Mitochondrial dysfunction plays a central role in the formation of neuroinflammation and oxidative stress,which are important factors contributing to the development of brain disease.Ample evidence suggests mitochondria are a promising target for neuroprotection.Recently,methods targeting mitochondria have been considered as potential approaches for treatment of brain disease through the inhibition of inflammation and oxidative injury.This review will discuss two widely studied approaches for the improvement of brain mitochondrial respiration,methylene blue(MB)and photobiomodulation(PBM).MB is a widely studied drug with potential beneficial effects in animal models of brain disease,as well as limited human studies.Similarly,PBM is a non-invasive treatment that promotes energy production and reduces both oxidative stress and inflammation,and has garnered increasing attention in recent years.MB and PBM have similar beneficial effects on mitochondrial function,oxidative damage,inflammation,and subsequent behavioral symptoms.However,the mechanisms underlying the energy enhancing,antioxidant,and anti-inflammatory effects of MB and PBM differ.This review will focus on mitochondrial dysfunction in several different brain diseases and the pathological improvements following MB and PBM treatment.
出处 《Translational Neurodegeneration》 SCIE CAS 2020年第2期248-269,共22页 转化神经变性病(英文)
基金 This study was supported by research grants from the United States of America:NS086929 from the National Institute of Neurological Disorders and Stroke NIA00051 from National Institute of Aging,National Institutes of Health AHA00169 from American Heart Association
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  • 1傅继东,杨黄恬.心肌细胞发育过程中胞浆内钙稳态的调控[J].生理学报,2006,58(2):95-103. 被引量:5
  • 2Aiken CT,Kaake RM,Wang X,et al.Oxidative stress-mediated regulation of proteasome complexes.Mol Cell Proteomics.in press.
  • 3Ienco EC,LoGerfo A,Carlesi C,et al.Oxidative stress treatment for clinical trials in neurodegenerative diseases.J Alzheimers Dis.2011;24 Suppl 2:111-126.
  • 4Fulda S,Gorman AM,Hori O,et al.Cellular stress responses:cell survival and cell death.Int J Cell Biol.2010;2010:214074.
  • 5Martin LJ.Mitochondrial and cell death mechanisms in neurodegenerative diseases.Pharmaceuticals (Basel).2010;3:839-915.
  • 6Genestra M.Oxyl radicals,redox-sensitive signalling cascades and antioxidants.Cell Signal.2007;19:1807-1819.
  • 7Halliwell B.Free radicals,antioxidants,and human disease:curiosity,cause,or consequence? Lancet.1994;344:721-724.
  • 8Halliwell B.Biochemistry of oxidative stress.Biochem Soc Trans.2007;35:1147-1150.
  • 9Droge W.Free radicals in the physiological control of cell function.Physiological reviews.2002;82:47-95.
  • 10Young IS,Woodside JV.Antioxidants in health and disease.J Clin Pathol.2001;54:176-186.

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