摘要
目的探索学龄儿童氟暴露水平与甲状腺结构和功能之间是否存在关联,为防治甲状腺疾病和高氟危害提供流行病学证据。方法2019年在天津市历史高氟区选择3所小学,整群抽样法选取217名8~10岁儿童进行基本情况调查,同时采集尿样和血样进行尿碘、尿氟、甲状腺激素和抗体检测以及氟斑牙、甲状腺B超检查。结果不同尿氟儿童性别、年龄和BMI比较,差异均无统计学意义(P>0.05)。不同尿氟组儿童氟斑牙程度差异有统计学意义(χ^2=16.263,P=0.012),尿氟含量较高的儿童氟斑牙患病率较高。不同尿氟组儿童中甲状腺肿大、结节、甲减、亚甲减和抗体双阳分布情况差异均无统计学意义(P>0.05),抗体单阳人数分布差异有统计学意义(χ^2=8.697,P=0.034)。多因素Logistic分析未发现尿氟与抗体单阳之间存在相关性(P>0.05)。结论:相对于氟暴露水平低的儿童,氟暴露水平高的儿童抗体单阳率较高,但综合分析未发现尿氟水平与甲状腺结构及疾病之间存在关系。
Objective To explore the relationship between fluoride exposure levels and thyroid structure and function in school-age children,and to provide epidemiological evidence for the prevention and treatment of thyroid diseases and for the control of high fluoride hazards.Methods In 2019,217 children aged 8-10 years were selected from 3 primary schools in the historical high fluoride area of Tianjin.Basic information was collected by questionnaire surveys.Urine and blood samples were collected for the determination of urine iodine,urine fluoride,and thyroid hormone as well as antibodies.The dental fluorosis was examined by Dean’s method and the thyroid structure was examined by ultrasound.Results There was no significant difference in gender,age and BMI of children with different urine fluoride levels(P>0.05).There was significant difference in the degree of dental fluorosis among children with different urine fluoride levels(χ^2=16.263,P=0.012),and the prevalence of dental fluorosis was higher in children with higher urine fluorine level.There was no significant difference in goiter,nodule,hypothyroidism,hypothyroidism and antibody double positive distribution among children with different urine fluoride levels(P>0.05),but the distribution of TGAb+or TPOAb+showed significant difference(χ^2=8.697,P=0.034).Logistic analysis showed that there was no correlation between urinary fluoride level and antibody single positive(P>0.05).Conclusion Compared with children with low fluoride exposure levels,children with high fluoride exposure have higher antibody single positive rate,but comprehensive analysis do not find a positive correlation between urinary fluoride level and thyroid structure and disease.
作者
曹立春
袁乃娟
李文凤
CAO Lichun;YUAN Naijuan;LI Wenfeng(Da Zhangzhuang Community Healthcare Service Center,Beichen District of Tianjin,Tianjin 300405,China;Tianjin Center for Disease Control and Prevention,Tianjin 300011,China)
出处
《公共卫生与预防医学》
2020年第5期72-75,共4页
Journal of Public Health and Preventive Medicine
基金
天津市卫生行业高层次人才津门医学英才项目(2018)。
关键词
儿童
尿氟
甲状腺
抗体
Children
Urinary fluoride
Thyroid
Antibody
