摘要
背景:透明质酸钠注射已用于许多肌肉骨骼疾病,包括膝关节骨性关节炎、肩周炎、类风湿性关节炎和其他肌腱软组织疼痛。目的:评价透明质酸钠与皮质类固醇治疗足底筋膜炎的效果。方法:65例足底筋膜炎患者随机分为2组,透明质酸钠组32例、皮质类固醇组33例。两组患者分别在超声引导下注射透明质酸钠2.5 mL(25 mg/2.5 mL)和复方倍他米松(二丙酸倍他米松5 mg,倍他米松磷酸钠2 mg),治疗间隔7d,共2次。分别在治疗前、治疗后1,3个月测量目测类比评分、足底筋膜厚度及AOFAS踝-后足功能评分。研究方案经青岛市市立医院伦理委员会批准,患者对治疗完全知情同意,并自愿完成治疗前后的评估、测试及随访。结果与结论:①治疗后1个月时与治疗前比较,两组目测类比评分、足底筋膜厚度下降,AOFAS踝-后足功能评分升高(P<0.05),其中皮质类固醇组目测类比评分显著低于透明质酸钠组(P<0.05);治疗后3个月与治疗后1个月时比较,两组治疗效果显著改善(P<0.05),两组之间评价指标差异无显著性意义(P>0.05);②皮质类固醇和透明质酸钠都能有效治疗足底筋膜炎,但短期1个月内皮质类固醇治疗效果更佳;为避免皮质类固醇治疗的潜在风险,透明质酸钠可以替代皮质类固醇治疗。
BACKGROUND:Sodium hyaluronate injection has been used in many musculoskeletal diseases,including knee osteoarthritis,frozen shoulder,rheumatoid arthritis,and other tendon and soft tissue pain.OBJECTIVE:To evaluate the effect of sodium hyaluronate injection and corticosteroid injection in reducing the symptoms of plantar fasciitis.METHODS:Sixty-five patients with plantar fasciitis were randomly divided into two groups:sodium hyaluronate group(32 cases)and corticosteroid group(33 cases).Two groups of patients were injected with 2.5 mL of sodium hyaluronate(25 mg/2.5 mL)and compound betamethasone(5 mg of diprosone and 2 mg of betamethasone sodium phosphate)under the guidance of ultrasound,respectively.The treatment interval was 7 days,twice in total.The Visual Analogue Scale(VAS)score,plantar fascia thickness and the American Orthopaedic Foot and Ankle Society(AOFAS)ankle-hindfoot score were measured before treatment,1 month and 3 months after treatment.RESULTS AND CONCLUSION:At 1 month after treatment,compared with the baseline data,the VAS and plantar fascia thickness of the two groups decreased,and the AOFAS ankle-hindfoot score increased(P<0.05).Moreover,the VAS score of the corticosteroid group was significantly lower than that of the sodium hyaluronate group(P<0.05).At 3 months after treatment,compared with the data at 1 month after treatment,the treatment effect was significantly improved in both two groups(P<0.05),and there was no significant difference between the two groups(P>0.05).To conclude,corticosteroids and sodium hyaluronate are both effective to treat plantar fasciitis,but the effect of corticosteroids is better within 1 month.To avoid the potential risk of corticosteroids,sodium hyaluronate can be a substitute of corticosteroids.
作者
张艺岑
王培鑫
刘志成
Zhang Yicen;Wang Peixin;Liu Zhicheng(Department of Cardiac Ultrasound,East Branch of Qingdao Municipal Hospital,Qingdao 266000,Shandong Province,China;First Department of General Surgery,East Branch of Qingdao Municipal Hospital,Qingdao 266000,Shandong Province,China;Department of Sports Medicine,East Branch of Qingdao Municipal Hospital,Qingdao 266000,Shandong Province,China)
出处
《中国组织工程研究》
CAS
北大核心
2021年第11期1670-1674,共5页
Chinese Journal of Tissue Engineering Research
关键词
足
筋膜炎
足底筋膜炎
透明质酸
皮质类固醇
筋膜厚度
疼痛
足踝功能
foot
fasciitis
plantar fasciitis
hyaluronic acid
corticosteroid
plantar fascia thickness
pain
ankle function
