摘要
多核破骨细胞具有骨吸收功能,其过度活化会导致骨破坏。在多种刺激诱导下,破骨前体细胞在其表达的融合相关分子(如树突状细胞特异性跨膜蛋白、破骨细胞多次跨膜蛋白、白细胞分化抗原、ATP6vOd2、E-钙黏蛋白、轻链钙调蛋白结合蛋白等)作用下,融合形成多核破骨细胞。由于破骨细胞融合过程对破骨细胞成熟及发挥骨吸收功能至关重要,因此,基于调节破骨细胞融合相关分子的研究可为骨质疏松、类风湿性关节炎、肿瘤等诱导的骨破坏提供新的治疗思路和方法。本文对破骨细胞融合相关分子的研究进展进行综述,旨在为骨破坏相关疾病的预防和治疗提供新方向。
Multinucleated osteoclasts exert bone resorption function that may lead to the occurrence of corresponding bone destruction through excessive activation.Osteoclast precursor cells(OPC)fuse to form giant multinucleated cells in a variety of ways under different stimuli through the functioning of fusion-related molecules expressed on OPC,like dendritic cells-specific transmembrane protein,osteoclast-stimulatory transmembrane protein,leukocyte differentiation antigen,ATP6vOd2,E-cadherin,light-chain caldesmon,etc.As fusion process is critical for the maturation of osteoclast and functions of bone resorption,new strategies and ideas of treating bone destruction disorders induced by osteoporosis,rheumatoid arthritis and tumors can be sought based on the regulation of cell fusion-associated molecules.This paper reviews the research progress of osteoclast fusion related molecules,aiming to provide novel directions for the prevention and treatment of bone destruction related diseases.
作者
邹斌华
郑洁煌
李晓娟
ZOU Binhua;ZHENG Jiehuang;LI Xiaojuan(Laboratory of Anti-inflammatory and Immunomodulatory Pharmacology,School of Pharmaceutical Sciences,Southern Medical University,Guangzhou,Guangdong 510515,China)
出处
《中国骨科临床与基础研究杂志》
2020年第3期161-168,共8页
Chinese Orthopaedic Journal of Clinical and Basic Research
基金
国家自然科学基金面上项目(81773740)
广州市科技计划项目(201804010027)。
关键词
破骨细胞
骨质吸收
骨生成
细胞融合
融合分子
骨破坏
分子靶向治疗
Osteoclasts
Bone resorption
Osteogenesis
Cell fusion
Fusion molecules
Bone destruction
Molecular targeted therapy
