摘要
目的分析头孢类抗菌药在临床治疗过程中发生的不良反应及其特点和规律。方法回顾性分析2017年7月至2019年7月常州市妇幼保健院应用头孢类抗菌药所导致的药物不良反应患者100例的临床资料,判断头孢类抗菌药物的不良反应用特点。结果①女性药物不良反应的发生概率明显高于男性,两组比较差异有统计学意义(P<0.05)。②新生儿及老年患者的药物不良反应发病率较高,与其他年龄段的患者相比,差异有统计学意义(P<0.05)。③导致头孢类抗菌药出现药物不良反应的原因较为复杂,给药途径会直接影响患者的药物不良反应发生率,静脉滴注是最大的致病因素,主要的药物有头孢吡肟、头孢奥曲松及头孢唑林。结论导致头孢类抗菌药出现药物不良反应的原因较多,在临床治疗上应注意不良反应的监测,合理用药是有效减少药物不良反应的重要手段。
Objective To study the adverse reactions of cephalosporins in clinical treatment and their characteristics and regularities.Methods The clinical data of 100 patients with adverse drug reactions caused by cephalosporin antibiotics used in Changzhou Maternal and Child Health Hospital from July 2017 to July 2019 were analyzed retrospectively,and the characteristics of adverse drug reactions caused by cephalosporin antibiotics were determined.Results①The incidence of adverse drug reactions in women was significantly higher than that in men,and the difference between the two groups was significant(P<0.05).②The incidence of adverse drug reactions in neonates and elderly patients was higher,which had statistical significance compared with other age groups(P<0.05).③The causes of adverse drug reactions of cephalosporins are complex.The route of administration will directly affect the incidence of adverse drug reactions in patients.The most important pathogenic factors during intravenous drip are cefepime,ceftriaxone and cefazolin.Conclusion There are many reasons leading to adverse drug reactions of cephalosporins.We should pay attention to the monitoring of adverse drug reactions in clinical treatment.Rational use of drugs in clinic is an important means to effectively reduce adverse drug reactions.
作者
叶波
顾庆
YE Bo;GU Qing(Changzhou Maternal and Child Health Hospital,Changzhou,Jiangsu 213023,China;Zouqu Town Health Center,Zhonglou District,Changzhou,Jiangsu 213144,China)
出处
《大医生》
2020年第8期93-93,94,95,共3页
Doctor
关键词
头孢类
抗菌药
cephalosporins
adverse reactions
