摘要
Clostridium species,as a predominant cluster of commensal bacteria in our gut,exert lots of salutary effects on our intestinal homeostasis.Up to now,Clostridium species have been reported to attenuate inflammation and allergic diseases effectively owing to their distinctive biological activities.Their cellular components and metabolites,like butyrate,secondary bile acids and indolepropionic acid,play a probiotic role primarily through energizing intestinal epithelial cells,strengthening intestinal barrier and interacting with immune system.In turn,our diets and physical state of body can shape unique pattern of Clostridium species in gut.In view of their salutary performances,Clostridium species have a huge potential as probiotics.However,there are still some nonnegligible risks and challenges in approaching application of them.Given this,this review summarized the researches involved in benefits and potential risks of Clostridium species to our health,in order to develop Clostridium species as novel probiotics for human health and animal production.
基金
This study was supported by the National Key R&D Program of China(2018YFD0500601 and 2017YFD0500501)
the National Natural Science Foundation of China(31930106,31829004 and 31722054)
the Beijing Nova Programme Interdisciplinary Cooperation Project(xxjc201804)
the 111 Project(B16044)
and the Developmental Fund for Animal Science by Shenzhen Jinxinnong Feed Co.,Ltd.
