摘要
阿尔茨海默病(AD)是最常见的神经退行性疾病之一,临床表现为认知和记忆功能障碍。钙蛋白酶(calpain)在细胞中广泛地被激活,钙蛋白酶的紊乱会引起AD病理学中tau蛋白过度磷酸化和tau蛋白的异常剪切。钙蛋白酶通过影响糖原合成酶激酶3和蛋白磷酸酶2A的活性,从而使tau蛋白多个位点发生异常过度磷酸化,并且介导tau蛋白单体的截断,诱导神经变性。钙蛋白酶有望成为AD药物治疗的潜在靶点。
Alzheimer's disease(AD)is one of the most common neurodegenerative diseases,which is characterized by cognitive and memory dysfunction.Calpain is widely activated in cells.Disturbance of calpain is currently thought to a main cause of hyperphosphorylation and abnormal cleavage of tau protein in AD pathology.Calpain affects the activities of glycogen synthase kinase 3 and protein phosphatase 2A,which causes abnormal hyperphosphorylation of multiple sites of tau protein,and mediates truncation of tau protein monomers,and induces neurodegeneration.Calpain is expected to be a potential target for drug therapy of AD.
作者
郭凯文
杨翠翠
张兰
GUO Kai-wen;YANG Cui-cui;ZHANG Lan(Department of Pharmacy,Xuanwu Hospital Capital Medical University/Beijing Engineering Research Center for Neurological Drugs/Laboratory of Brain Disorders,Ministry of Science and Technology/Key Laboratory of Neurodegenerative Diseases,Ministry of Education,Beijing 100053,China)
出处
《中国康复理论与实践》
CSCD
北大核心
2020年第10期1182-1185,共4页
Chinese Journal of Rehabilitation Theory and Practice
基金
国家自然科学基金项目(No.81874351,No.81703729)
北京市高层次卫生技术人才计划项目(No.2014-2-014)。
