摘要
目的探讨甲泼尼龙联合阿奇霉素治疗肺炎支原体感染性大叶性肺炎患儿的临床效果。方法选取2017年10月~2018年10月我院收治的86例肺炎支原体感染性大叶性肺炎患儿的临床资料,按照治疗方案将其分为对照组和观察组,每组各43例。对照组采用阿奇霉素治疗,观察组采用甲泼尼龙联合阿奇霉素治疗。比较两组患儿的疗效、住院时间、症状恢复时间(肺部阴影吸收、肺部啰音消失、退热),治疗前及治疗2周后肺功能[呼气峰流速(PEF)、用力肺活量(FVC)、第1秒用力呼气容积(FEV1)]及炎症状态[血清C反应蛋白(CRP)、白介素-8(IL-8)、白介素-6(IL-6)]。结果观察组的总有效率为97.67%,高于对照组的81.40%,差异有统计学意义(P<0.05);观察组住院时间、肺部阴影吸收时间、肺部啰音消失时间、退热时间均短于对照组,差异有统计学意义(P<0.05);治疗2周后,观察组的PEF、FVC、FEV1水平均高于对照组,血清CRP、IL-8、IL-6水平均低于对照组,差异有统计学意义(P<0.05)。结论甲泼尼龙联合阿奇霉素治疗肺炎支原体感染性大叶性肺炎患儿效果显著,能缩短症状恢复时间、住院时间,改善患儿的肺功能,减轻炎症状态。
Objective To explore the clinical effect of Methylprednisolone combined with Azithromycin in the treatment of children with Mycoplasma pneumoniae infectious lobar pneumonia.Methods The clinical data of 86 children with Mycoplasma pneumoniae infectious lobar pneumonia in our hospital from October 2017 to October 2018 were selected,they were divided into control group and observation group according to the treatment plan,43 cases in each group.The control group was treated with Azithromycin,the observation group was treated with Methylprednisolone and Azithromycin.The efficacy,hospitalization time,symptom recovery time(absorption of lung shadows,disappearance of lung rales and and antipyretic)between the two groups were compared,and lung function(peak expiratory flow rate[PEF],forced vital capacity[FVC],forced expiratory volume in the first second[FEV1])and inflammatory state(serum C-reactive protein[CRP],interleukin-8[IL-8],interleukin-6[IL-6])before treatment and two weeks after treatment between the two groups were compared.Results The total effective rate in the observation group was 97.67%,which was higher than that in the control group of 81.40%,the difference was statistically significant(P<0.05).The hospitalization time,lung shadow absorption time,lung rales disappearance time and antipyretic time in the observation group were shorter than those in the control group,the differences were statistically significant(P<0.05).After two weeks of treatment,the levels of PEF,FVC and FEV1 in the observation group were higher than those in the control group,and the levels of serum CRP,IL-8 and IL-6 in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion The combination of Methylprednisolone and Azithromycin has a significant effect on Mycoplasma pneumoniae infectious lobar pneumonia,which can shorten the recovery time of symptoms and hospitalization time,improve lung function of the children,and reduce the inflammation state.
作者
王岩
黄雅玲
WANG Yan;HUANG Ya-ling(Department of Pediatrics,Fuxin Mine General Hospital of Liaojian Group in Fuxin City,Liaoning Province,Fuxin123000,China)
出处
《中国当代医药》
2020年第28期150-153,共4页
China Modern Medicine
关键词
甲泼尼龙
阿奇霉素
肺炎支原体感染性大叶性肺炎
症状恢复时间
肺功能
炎症状态
Methylprednisolone
Azithromycin
Mycoplasma pneumoniae infectious lobar pneumonia
Time to recovery of symptoms
Lung function
Inflammatory state
