摘要
肺纤维化为许多慢性肺部疾病共同的病理结局。益肺散结方为云南省名中医李庆生教授治疗该疾病的临床经验方。对该方防治肺纤维化作用机制进行总结分析,发现该方主要活性成分为黄芪多糖、三七总皂苷、姜黄素、莪术醇等,可通过多个靶点调控PI3K/AKT信号通路、TGF-β1/Smad信号通路、NF-κB信号通路、MAPK信号通路等,发挥免疫调节、抗炎等的作用,干预肺纤维化的发生发展。
Pulmonary fibrosis is a common and irreversible pathological outcome of many chronic lung diseases.Yifei Sanjie prescription is an experiential prescription in treating pulmonary fibrosis.The prescription is authorized by professor Qingshen Li,a famous physician in traditional Chinese medicine in Yunnan Province.This paper analyzed and summarized its mechanisms in preventing and treating pulmonary fibrosis.Results suggested that,the active ingredients included the astragalus polysaccharides,total notoginseng saponins,curcumin,and curcumenol;which play important roles in immune regulation and anti-inflammation to alleviate pulmonary fibrosis by regulating PI3K/AKT signaling pathway,TGF-beta1/Smad signaling pathway,NF-kappa B signaling pathway,and MAPK signaling pathway.
作者
乔波
吴月滢
李小雅
胡雅楠
贾文清
邢海晶
段为钢
QIAO Bo;WU Yueying;LI Xiaoya;HU Yanan;JIA Wenqing;XING Haijing;DUAN Weigang(School of Basic Medical Science,Yunnan University of Chinese Medicine,Kunming 650500,China;School of First Clinical Medical Science,Yunnan University of Chinese Medicine,Kunming 650500,China;School of Chinese Medical Science,Hunan University of Chinese Medicine,Changsha 410208,China;The Key Laboratory of Molecular Biology of Traditional Chinese Medicine,Kunming 650500,China)
出处
《云南中医学院学报》
2020年第2期97-102,共6页
Journal of Yunnan University of Traditional Chinese Medicine
基金
云南省中医药学分子生物学重点实验室(2019DG016)。
关键词
益肺散结方
肺纤维化
作用机制
免疫调节
抗炎
Yifei Sanjie prescription
pulmonary fibrosis
mechanism
immune regulation
anti-inflammation
