摘要
胆道恶性肿瘤指来源于胆道上皮的恶性肿瘤,其发病率与病因学均存在地域差异,综合基因组学的进展已经发现了不同基因驱动因子的异常。大量研究证实胆管癌不仅具有隐匿性、侵袭性、难治性等特点,且肿瘤呈现出瘤间与瘤内的多层次异质性,受到不同危险因素相互作用的影响。深入了解其生物学特性对开展进一步研究,提供更准确的诊断,制定更有效的治疗等具有重要意义。本文拟对胆管癌生物学特性做一综述。
Biliary malignancy refers to malignant tumors originating from the biliary epithelium,whose incidence and etiology vary geographically.The progress of comprehensive genomics has found abnormalities in different gene drivers.Advances in comprehensive genomics have revealed abnormalities in different gene drivers.A large number of studies have confirmed that cholangiocarcinoma not only has the characteristics of concealability,invasiveness and refractory,but also presents the multilevel heterogeneity between tumor and intratumor,which is affected by the interaction of different risk factors.Further understanding of its biological characteristics is of great significance for further research,more accurate diagnosis and more effective treatment.The purpose of this article was to review the biological characteristics of biliary tract cancer.
作者
李博
曹坤
左石
LI Bo;CAO Kun;ZUO Shi(Department of Hepato-biliary Surgery,the Affiliated Hospital of Guizhou Medical University,Guiyang 550004,China)
出处
《临床外科杂志》
2020年第8期790-792,共3页
Journal of Clinical Surgery
基金
贵州省优秀青年科技人才专项基金资助项目([2019]5628)
贵州省科学技术基金资助项目(黔科合基础[2018]1127)。
关键词
胆道恶性肿瘤
生物学特性
biliary tract cancer
biological characteristics
