摘要
目的探讨特拉唑嗪结合经尿道前列腺电切术(TURP)治疗良性前列腺增生(BPH)的临床疗效及对患者性功能的影响。方法选取洪湖市人民医院2018年收治的BPH患者100例,按入院顺序编号,采用奇偶数法分为治疗组和对照组,各50例。两组患者均在完善泌尿系统B超、前列腺CT、尿流率等常规检查后予TURP,治疗组患者围术期(术前2周至术后2周)口服盐酸特拉唑嗪片。结果治疗组总有效率为96.00%,显著高于对照组的84.00%(P<0.05);治疗后,治疗组患者的膀胱残余尿量、最大尿流量、国际前列腺症状评分(IPSS)、再置管率及下尿路症状发生率均显著低于对照组(P<0.05),最大尿流率、国际勃起功能指数-5评分(IIEF-5)均显著高于对照组(P<0.05),留置尿管时间显著短于对照组(P<0.05);治疗组与对照组的不良反应发生率相当(8.00%比4.00%,P>0.05)。结论TURP联合特拉唑嗪治疗BPH能缩短留置尿管时间,改善排尿障碍,缓解术后下尿路症状及性功能障碍。
Objective To explore and discuss the clinical efficacy and influence on sexual function of terazosin combined with transurethral resection of prostate(TURP)for benign prostatic hyperplasia(BPH).Methods A total of 100 patients with BPH from January 2018 to December 2018 in Honghu People’s Hospital were selected and numbered according to their admittance order;then they were divided into the treatment group and control group by using the odd-even number method,50 cases in each group.All patients received TURP operation after routine examinations such as B-ultrasound of the urinary system,CT of the prostate,and urine flow rate;the treatment group took terazosin hydrochloride tablets orally during the perioperative period(from 2 weeks before surgery to2 weeks after surgery).Results The total effective rate of the treatment group was 96.00%,which was significantly higher than84.00%in the control group(P<0.05);after treatment,the bladder residual urine volume,maximum urine flow,international prostate symptom score(IPSS),reinsertion rate,and incidence of lower urine symptoms in the treatment group were significantly lower than those in the control group(P<0.05);the maximum urinary flow rate,the International Index of Erectile Function-5 score(IIEF-5)were significantly higher than those of the control group(P<0.05);the indwelling catheter time was significantly shorter than the control group(P<0.05).The incidence of adverse reactions in the treatment group and the control group was equivalent(8.00%vs.4.00%,P>0.05).Conclusion TURP combined with terazosin in the treatment of BPH can shorten the indwelling catheter time,improve urination disorders,and relieve postoperative lower urinary tract symptoms and sexual dysfunction.
作者
曾爱兵
张瑞
ZENG Aibing;ZHANG Rui(Honghu People's Hospital,Jingzhou,Hubei,China 434000;Jingzhou First People's Hospital,Jingzhou,Hubei,China 434000)
出处
《中国药业》
CAS
2020年第20期75-78,共4页
China Pharmaceuticals
基金
湖北省自然科学基金[2016CFB742]。
关键词
特拉唑嗪
经尿道前列腺电切术
良性前列腺增生
围术期
临床疗效
terazosin
transurethral resection of prostate
benign prostatic hyperplasia
perioperative period
clinical efficacy
