摘要
目的:观察中药熏洗联合外用依托芬那酯凝胶治疗轻中度膝骨关节炎的临床效果。方法:选取华中科技大学同济医学院附属同济医院2018年9月至2019年4月治疗的轻中度膝骨关节炎患者176例为研究对象,采用随机数字表法分为对照组85例、观察组91例,对照组采用单纯外用依托芬那酯凝胶治疗,观察组采用中药熏洗联合外用依托芬那酯凝胶治疗,两组疗程均为2周。比较两组治疗前后国际骨关节炎评分标准(Lequesne指数)及临床疗效。结果:治疗后1 d及治疗后2周,两组Lequesne总指数差异均无统计学意义(均P>0.05);治疗后1个月、治疗后个3月,观察组Lequesne总指数分别为(4.1±1.1)分、(4.6±1.0)分,均显著低于对照组的(6.2±1.2)分、(7.5±1.4)分(t=12.155、15.598,均P<0.05)。治疗后1 d及治疗后2周,两组有效率差异均无统计学意义(均P>0.05);治疗后1个月、治疗后3个月,观察组有效率分别为63.7%(58/91)、61.5%(56/91),均高于对照组的41.2%(35/85)、18.8%(16/85),差异均有统计学意义(χ2=8.98、33.17,均P<0.05)。结论:中药熏洗联合外用依托芬那酯凝胶治疗轻中度膝骨关节炎起效快、疗效持久,效果优于单纯外用依托芬那酯凝胶治疗。
Objective:To explore the clinical effect of traditional Chinese medicine(TCM)fumigation-washing therapy combined with etofenamate cream wiping in the treatment of knee osteoarthritis.Methods:From September 2018 to April 2019,176 cases of knee osteoarthritis were divided into two groups according to random number table method.The observation group(91 cases)was treated by etofenamate cream based on fumigation-washing therapy with TCM,while the control group(85 cases)was treated by etofenamate cream wiping only.Both two groups continued treatment for 2 weeks.The Lequesne score and effective rate of the two groups were achieved and analyzed.Results:At 1 d and 2 weeks after treatment,there were no statistically significant differences in the Lequesne score between the two groups(all P>0.05).After treatment for 1 month and 3 months,Lequesne scores of the observation group[(4.1±1.1)points,(4.6±1.0)points]were lower than those of the control group[(6.2±1.2)points,(7.5±1.4)points](t=12.155,15.598,all P<0.05).At 1 d and 2 weeks after treatment,there were no statistically significant difference in the effective rate between the two groups(all P>0.05).After treatment for 1 month and 3 months,the effective rates of the observation group were 63.7%(58/91)and 61.5%(56/91),respectively,which were higher than those of the control group[41.2%(35/85)and 18.8%(16/85)](χ2=8.98,33.17,all P<0.05).Conclusion:Fumigation-washing therapy with TCM combined with etofenamate cream wiping has quick,lasting and safe effect in the treatment of knee osteoarthritis.
作者
程鹏
罗永湘
陈安民
Cheng Peng;Luo Yongxiang;Chen Anmin(Department of Orthopedics,Tongji Hospital of Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430030,China)
出处
《中国基层医药》
CAS
2020年第19期2353-2356,共4页
Chinese Journal of Primary Medicine and Pharmacy
关键词
骨关节炎
膝
药物疗法
联合
中草药
投药
局部
熏洗
依托芬那酯凝胶
疗效比较研究
Osteoarthritis,knee
Drugtherapy,combination
Drugs,chinese herbal
Administration,topical
Fumigating and washing
Etofenamate
Comparative effectiveness research
