摘要
目的分析原发性肝癌(HCC)经切除术后联合肝动脉介入化疗栓塞术(TACE)对患者血清学肿瘤标志物水平、生存质量的影响。方法将我院2016年1月至2017年12月收治的90例HCC患者根据治疗方式分为对照组和观察组,各45例。两组均接受腹腔镜肝癌切除术治疗,观察组在术后1周联合TACE治疗。比较两组的治疗效果。结果术后1、2年,观察组患者的生存率高于对照组,复发率低于对照组(P<0.05)。T1时,观察组的CP评分、TBIL、ALT、AST水平均高于对照组(P<0.05)。治疗后,观察组患者的AFP、GPC3、CA19-9、TK1水平均低于对照组,QOL-LC评分均高于对照组(P<0.05)。结论HCC经切除术联合TACE可降低复发率,提高生存质量,虽短期内会对肝功能造成损伤,但整体效果显著。
Objective To analyze the effect of transcatheter arterial chemoembolization(TACE)after resection on serum tumor markers levels and quality of life in patients with primary hepatic carcinoma(HCC).Methods A total of 90 cases with HCC treated in our hospital from January 2016 to December 2017 were divided into control group and observation group according to the treatment method,with 45 cases in each group.The two groups were treated with laparoscopic hepatectomy,and the observation group was treated with TACE at 1 week after operation.The therapeutic effects of the two groups were compared.Results After 1 and 2 years,the survival rate of the observation group were higher than those of the control group,and the recurrence rate were lower than those of the control group(P<0.05).At T1,the CP score,TBIL,ALT and AST levels of the observation group were higher than those of the control group(P<0.05).After treatment,the levels of AFP,GPC3,CA19-9 and TK1 of the observation group were lower than those of the control group,and the QOL-LC scores were higher than those of the control group(P<0.05).Conclusion The TACE after resection in HCC can reduce the recurrence rate and improve the quality of life.Although it can damage the liver function in a short time,the overall effect is significant.
作者
王崇宝
高娜
WANG Chongbao;GAO Na(Shaanxi Traditional Chinese Medicine Hospital,Xi'an 710003,China)
出处
《临床医学研究与实践》
2020年第30期18-20,共3页
Clinical Research and Practice
基金
陕西省2020年重点研发计划项目(No.2020SF-067)。
关键词
原发性肝癌
肝动脉化疗栓塞
血清肿瘤标志物
primary hepatic carcinoma
transcatheter arterial chemoembolization
serum tumor markers
