摘要
目的系统评价金水宝胶囊联合血管紧张素转换酶抑制剂(ACEI)对糖尿病肾病的疗效。方法检索中国期刊全文数据库(CNKI)、中国生物医学文献数据库(CBM)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(维普网)、PubMed、Embase,收集金水宝胶囊联合ACEI治疗糖尿病肾病的随机对照试验(RCT)。检索范围为建库至2019年5月31日,采用RevMan5.3进行Meta分析。结果共纳入14篇RCT,涉及患者1067例。观察组(金水宝胶囊联合ACEI)治疗糖尿病肾病的总有效率高于对照组,差异有统计学意义(OR=5.74,95%CI[3.29,10.03],Z=6.14,P<0.00001);2组24 h尿蛋白定量、尿微量白蛋白排泄率、血肌酐、血尿素氮比较差异有统计学意义(P<0.00001)。2组均未见严重不良反应。结论金水宝胶囊联合ACEI治疗糖尿病肾病疗效较好,安全性高。由于纳入研究质量不一,确切结论尚需更多大样本、高质量RCT予以证实。
Objective To systematically evaluate the efficacy of Jinshuibao Capsules combined with angiotensin converting enzyme inhibitor(ACEI)for the treatment of diabetic nephropathy(DN).Methods Randomized controlled trials of modified Jinshuibao Capsules combined with ACEI for the treatment of DN were retrieved from CNKI,CBM,Wanfang Data,VIP,Pubmed and Embase.The search scope was from the construction of the databases to May 31,2019.RevMan 5.3 was used for meta-analysis.Results A total of 14 RCTs were included in the study,including 1067 patients.The total effective rate of Jinshuibao Capsules combined with ACEI in the treatment of DN was higher than that in the control group,with statistical significance(OR=5.74,95%CI[3.29,10.03],Z=6.14,P<0.00001);There was statistical significance in 24 h urine protein excretion,urine microalbumin excretion rate,serum creatinine,and blood urea nitrogen between the two groups(P<0.00001).No serious adverse reactions were reported in either group.Conclusion Jinshuibao Capsules combined with ACEI is effective and safe in the treatment of DN.However,due to the inconsistent quality of the included studies,this conclusion needs to be confirmed by more large-scale,high-quality clinical randomized controlled trials.
作者
连心逸
柳红芳
王向明
章轶立
LIAN Xinyi;LIU Hongfang;WANG Xiangming;ZHANG Yili(The First Clinical Medical College of Beijing University of Chinese Medicine,Beijing 100700,China;Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China)
出处
《中国中医药信息杂志》
CAS
CSCD
2020年第9期103-107,共5页
Chinese Journal of Information on Traditional Chinese Medicine
基金
国家自然科学基金(81774273)。
关键词
金水宝胶囊
血管紧张素转换酶抑制剂
糖尿病肾病
系统评价
Jinshuibao Capsules
angiotensin converting enzyme inhibitor
diabetic nephropathy
meta-analysis
