摘要
随着腔内介入诊断及治疗的广泛应用,对比剂急性肾损伤(contrast-induced acute kidney injury,CI-AKI)的发病率急剧上升,其发生增加了患者的长、短期病死率并延长住院时间。对于CI-AKI发病机制的研究以及进行预防和防治是临床医生密切关心的问题,而研究的基础是建立疾病的动物模型。本文对一些常用和成熟的CI-AKI动物模型的建立机制和方法进行了总结,为CI-AKI的基础发病机制研究与药物筛选和有效性评价提供参考。
With the wide application of endovascular interventional diagnosis and treatment,the incidence of contrast-induced acute kidney injury(CI-AKI)increases sharply,which increases the long-term and short-term mortality and prolongs the duration of hospitalization.Research focusing on the pathogenesis research,prevention and treatment of CI-AKI were closely concerned by clinicians,and relative basic research was totally based on animal model establishment.In this review,the establishment methods and basic mechanism of prevalent and mature animal models of CI-AKI were summarized,in order to provide reference for the basic pathogenesis,drug screening and effectiveness evaluation of contrast-induced acute kidney injury.
作者
王豆豆
胡杰
袁萌
高婷婷
董红霖
WANG Dou-dou;HU Jie;YUAN Meng;GAO Ting-ting;DONG Hong-lin(Department of Vascular Surgery,the Second Hospital of Shanxi Medical University,Taiyuan 030000,China)
出处
《临床肾脏病杂志》
2020年第10期842-845,共4页
Journal Of Clinical Nephrology
关键词
对比剂
急性肾损伤
动物模型
Contrast media
Acute renal injury
Animal model
