摘要
目的探讨特应性皮炎患者血清25-(OH)D水平与病情轻重的相关性。方法选取2017年1月~2018年12月就诊于韶关市第一人民医院的特应性皮炎患者共49例,采用SCORAD评分将初诊特应性皮炎患者病情分为轻、中、重三组,检测血清25-(OH)D水平。比较不同组间血清25-(OH)D水平变化。对每组SCROAD分值及血清25-(OH)D水平作Pearson相关性检验。结果轻、中、重度组血清25-(OH)D水平分别为(37.64±10.44)ng/mL、(36.41±10.35)ng/mL、(22.81±7.58)ng/mL。血清25-(OH)D水平在轻、中度组间比较无统计学差异(t=0.497,P>0.05),轻、重度组间比较及中、重度组间比较,差异有统计学意义(t=5.984,P<0.05;t=5.138,P<0.05)。患者SCROAD分值及血清25-(OH)D水平具有显著负相关,Pearson相关系数为-0.47,P<0.05。结论特应性皮炎患者中,血清25-(OH)D水平随SCORAD评分升高而下降。在重度患者中的血清25-(OH)D水平较轻、中度时明显降低。血清25-(OH)D水平可以体现特应性皮炎患者疾病的严重程度。
Objective To explore the correlation between serum 25-(OH)D level and severity of atopic dermatitis.Methods A total of 49 patients with atopic dermatitis who were treated in Shaoguan First People's Hospital from January 2017 to December 2018 were divided into mild group,moderate group and heavy group by using SCORAD score.The serum 25-(OH)D level was detected.The changes of serum 25-(OH)D levels between different groups were compared.Pearson correlation test was performed on the SCROAD score and serum 25-(OH)D level of each group.Results The levels of serum 25-(OH)D in the mild,moderate and severe groups were(37.64±10.44)ng/mL,(36.41±10.35)ng/mL and(22.81±7.58)ng/mL,respectively.The serum 25-(OH)D level was not statistically different between the mild and moderate groups(t=0.497,P>0.05),while was significant different between the mild and severe groups(t=5.984,P<0.05)and between the moderate and severe groups(t=5.138,P<0.05).The patient's SCROAD score had a significant negative correlation with serum 25-(OH)D level.The Pearson correlation coefficient was-0.47,P<0.05.Conclusion In patients with atopic dermatitis,the serum 25-(OH)D level decreases as the SCORAD score increases.Serum 25-(OH)D levels were significantly lower in severe patients than in mild and moderate patients.Serum 25-(OH)D level can reflect the severity of disease in patients with atopic dermatitis.
作者
李珍
雷兴
LI Zhen;LEI Xing(Department of Dermatology,Shaoguan First People's Hospital in Guangdong Province,Shaoguan 512000,China)
出处
《中国现代医生》
2020年第26期16-19,共4页
China Modern Doctor
基金
广东省韶关市科技计划项目(2017cx/021)。
