摘要
目的:分析子宫肌瘤(UL)患者血清人附睾蛋白4(HE4)、血管内皮生长因子(VEGF)及性激素变化及预后转归。方法:选取2016年8月-2018年8月本院收治的UL患者150例,依据预后转归情况分为治疗成功组和治疗失败组,对比其手术前后HE4、VEGF及性激素[促卵泡刺激素(FSH)、孕酮(P)、雌二醇(E2)、黄体生成素(LH)]水平,采用受试者工作特征曲线(ROC)分析术前各指标对UL患者预后转归价值。结果:术后患者血清HE4、VEGF及性激素水平均下降(P<0.05),且治疗成功组HE4、VEGF、FSH、E2、LH水平均低于治疗失败组,术后6个月血清HE4、VEGF、FSH、E2水平仍低于治疗失败组(均P<0.05);ROC曲线分析显示,术前血清HE4、VEGF及FSH、E2、LH联合预测UL患者预后的灵敏度、特异度、准确度、曲线下面积分别为0.78%、0.65%、0.68%、0.653,均高于各指标单独预测。结论:UL患者血清HE4、VEGF及性激素在手术前后发生明显变化,联合检测对患者预后有较好的预测价值。
Objective: To analyze the changes of serum human epididymis protein 4(HE4), vascular endothelial growth factor(VEGF), and sex hormones of women with uterine leiomyoma(UL), and to study the prognosis of UL. Methods: 150 women with UL were selected as the subjects between August 2016 and August 2018. According to the prognosis, they were divided into group A(women with successful treatment) and group B(women with treatment failure). The levels of HE4, VEGF, and sex hormones, such as follicle stimulating hormone(FSH), progesterone(P), estradiol(E2), luteinizing hormone(LH) of all women were compared before and after operation. The receiver operating characteristic(ROC) curve was used to analyze the value of the levels of HE4, VEGF, and sex hormones for predicting the prognosis of patients with UL. Results: The levels of serum HE4, VEGF, FSH, P, E2 and LH of all women after operation had decreased significantly. The levels of serum HE4, VEGF, FSH, E2 and LH of women before operation in group A were significant lower than those of women in group B, and at 6 months after surgery, the levels of serum HE4, VEGF, FSH, and E2 of women before operation in group A were also significant lower than those of women in group B(P<0.05). ROC curve analysis showed that the sensitivity, the specificity, the accuracy, and the area under the curve of the combination of preoperative serum HE4, VEGF, FSH, E2 and LH levels for predicting the prognosis of UL were 0.78, 0.65, 0.68 and 0.653, respectively, which were significant higher than those of the serum HE4 level, VEGF level, FSH level, E2 level, or LH level alone. Conclusion: The levels of serum HE4, VEGF and sex hormones of women with UL have changed significantly after operation. The combined detection of HE4, VEGF and sex hormone levels has high value for predicting prognosis.
作者
周凤
周荣勇
李小莉
李立兴
陈涛
陈丽敏
ZHOU Feng;ZHOU Rongyong;LI Xiaoli;LI Lixing;CHEN Tao;CHEN Limin(People's Hospital of Jianyang,Sichuan Province,641500)
出处
《中国计划生育学杂志》
2020年第10期1617-1620,共4页
Chinese Journal of Family Planning
关键词
子宫肌瘤
人附睾蛋白4
血管内皮生长因子
性激素
手术预后预测价值
Uterine leiomyoma
Human epididymis protein 4
Vascular endothelial growth factor
Sex hormones
Prognosis
Post operational predicting value
