摘要
目的:研究分泌性中耳炎(SOM)患者血清可溶性白细胞介素2受体(SIL-2R)水平与T淋巴细胞亚群水平的相关性。方法:选取2015年3月至2019年12月本院收治的SOM患者235例作为观察组,另选取同期在本院进行体检的100例健康人群作为对照组。测定两组SIL-2R水平以及T淋巴细胞亚群相关指标水平,采用Pearson相关性分析SIL-2R与T淋巴细胞亚群水平的相关性。结果:观察组分化簇3(CD3)、分化簇4(CD4)、CD4/分化簇8(CD4/CD8)水平明显低于对照组(P<0.05),CD8水平明显高于对照组(P<0.05);观察组SIL-2R水平明显高于对照组(P<0.05);Person相关性分析显示血清sIL-2R水平与CD3、CD4、CD4/CD8呈显著负相关关系(P<0.05),与CD8呈显著正相关关系(P<0.05)。结论:SOM患者SIL-2R与T淋巴细胞亚群水平具有一定的相关性。
Objective:To study the correlation between serum soluble interleukin-2 receptor(SIL-2R)level and T lymphocyte subsets levels in secretory otitis media(SOM).Methods:A total of 235 patients with SOM admitted to the hospital from March 2015 to December 2019 were selected as observation group.Another 100 healthy people who underwent physical examination in our hospital at the same time period were selected as control group.The levels of SIL-2R and T lymphocyte subsets-related indexes were measured in the two groups.The correlation between SIL-2R and T lymphocyte subsets was analyzed by Pearson correlation.Results:The levels of CD3,CD4 and CD4/CD8 in the observation group were significantly lower than those in the control group(P<0.05),and the level of CD8 in the observation group was significantly higher than that in the control group(P<0.05).The level of SIL-2R in the observation group was significantly higher than that in the control group(P<0.05);the level of serum SIL-2R was significantly negatively correlated with CD3,CD4,CD4/CD8(P<0.05),and positively correlated with CD8(P<0.05).Conclusions:There is a certain correlation between SIL-2R and T lymphocyte subsets levels.
作者
陈璇
历东东
石燕
CHEN Xuan;LI Dongdong;SHI Yan(Kelamey Municipal Central Hospital,Xinjiang Kelamey 834000,China)
出处
《河北医学》
CAS
2020年第10期1623-1625,共3页
Hebei Medicine
基金
新疆克位玛依市创新人才工程科技项目基金,(编号:2018RC001A17)。
