摘要
目的:研究健脾化湿法对特应性皮炎(AD)患者的免疫调节作用。方法:选取于2017年4月至2018年5月广州中医药大学第二临床医学院收治的特应性皮炎患者88例作为研究对象,按照随机数字表法分为对照组和观察组,每组44例。对照组采用他克莫司软膏进行局部治疗,观察组在对照组的基础上予以健脾化湿中药汤剂,早晚各口服300 mL,2组均治疗1个月。比较2组治疗前后的SCORAD积分及免疫球蛋白E(IgE)、白细胞介素-4(IL-4)、白细胞介素-10(IL-10)、白细胞介素-12(IL-12)水平,并对2组的临床治疗效果进行评价。结果:治疗1个月后,2组患者的SCORAD积分、IL-4水平均显著降低(P<0.05),且观察组低于对照组(P<0.05)。治疗后观察组IgE、IL-4和IL-10水平均低于对照组(P<0.05),而IL-12水平明显高于对照组(P<0.05)。观察组的总有效率为86.36%,显著高于对照组(63.64%,P<0.05)。结论:健脾化湿法可以显著降低AD患者的SCORAD积分及免疫调节指标水平,有效缓解病情,具有较高的临床应用价值。
Objective:To study the immunoregulatory effects of Jianpi Huashi method on patients with atopic dermatitis(AD).Methods:A total of 88 AD patients who were treated in our Dermatology Department from April 2017 to May 2018 were selected.According to the random number table method,they were divided into a control group and an observation group,with 44 cases in each group.The control group was treated with tacrolimus ointment for local treatment,while the observation group was given Jianpi Huashi Decoction on the basis of the control group.Both groups were orally administered 300 mL each morning and evening and were treated for one month.The SCORAD score and immunoglobulin E(IgE),interleukin-4(IL-4),interleukin-10(IL-10),and interleukin-12(IL-12)levels were compared between the 2 groups before and after treatment,and the clinical curative effects of the 2 groups were evaluated.Results:After 1 month treatment,the scores of SCORAD and IL-4 level in the 2 groups significantly decreased(P<0.05),and the observation group was lower than the control group(P<0.05).After treatment,the levels of IgE,IL-4 and IL-10 in the observation group were lower than those in the control group(P<0.05),while the levels of IL-12 were significantly higher than those in the control group(P<0.05).The total effective rate of the observation group was 86.36%,which was significantly higher than that of the control group(63.64%,P<0.05).Conclusion:Jianpi Huashi method can significantly reduce the SCORAD score and immune regulation index levels of AD patients,effectively relieve the disease,which has higher clinical application value.
作者
王奕夫
邱宝山
李锦锦
康旭
WANG Yifu;QIU Baoshan;LI Jinjin;KANG Xu(The Second Clinical Medical College of Guangzhou University of Traditional Chinese Medicine,Guangzhou 510405,China;Department of Neurology,the First Affiliated Hospital of Zhongshan University,Guangzhou 510080,China;Department of Dermatology,Guangdong Hospital of Traditional Chinese Medicine, Guangzhou 510120,China)
出处
《世界中医药》
CAS
2020年第20期3109-3112,共4页
World Chinese Medicine
基金
广东省医学科学技术研究项目(A2017057)。
关键词
健脾化湿法
特应性皮炎
免疫调节
疗效
Jianpi Huashi method
Atopic dermatitis
Immune regulation
Curative effects
