摘要
目的观察玉屏风颗粒对儿童过敏性紫癜的疗效及探讨其对血清IgA、IgE、IgG和CD3^+、CD4^+、CD8^+淋巴细胞的影响。方法将60例患儿随机分为2组,每组各30例,对照组给予常规治疗,治疗组在常规治疗基础上加用玉屏风颗粒。疗程均为2周,30例同年龄段健康体检儿童为正常组。3组分别在治疗前后抽取清晨空腹外周静脉血,行IgA、IgE、IgG水平和CD3^+、CD4^+、CD8^+淋巴细胞数的检测。结果总有效率治疗组为96.7%,对照组为83.3%,2组比较差异有显著性意义(P<0.05)。治疗前治疗组和对照组IgA和IgE都较正常组明显升高(P<0.05),IgG无明显差异(P>0.05);治疗前治疗组和对照组CD3^+、CD4^+淋巴细胞百分率较正常组明显降低(P<0.05),CD8^+淋巴细胞百分率较正常组明显升高(P<0.05)。治疗后治疗组与对照组IgA、IgE水平均明显下降(P<0.05);治疗后此2组比较,差异也有显著性意义(P<0.05);2组IgG治疗前后比较,差异无显著性意义(P>0.05)。治疗组治疗后CD3^+、CD4^+淋巴细胞百分率较治疗前明显升高(P<0.05),CD8^+淋巴细胞百分率较治疗前明显下降(P<0.05);对照组治疗前后无显著性差异。结论过敏性紫癜患儿存在显著的体液免疫和细胞免疫紊乱,玉屏风颗粒能有效纠正疾病的免疫紊乱状态,临床疗效显著。
Objective To observe the clinical efficacy of Yupingfeng on children with Henoch-Schonlein purpura(HSP)and explore its effect on the levels of serum IgA,IgE,IgG and CD3^+,CD4^+,CD8^+lymphocyte subsets.Methods 60 children were randomly divided into 2 groups,30 cases in each group.The control group was given conventional treatment,while the treatment group was additionally received Yupingfeng granules.The course of treatment lasted for 2 weeks,and 30 healthy children of the same age were included as the normal group.Peripheral vein blood was collected from three groups'children respectively before and after treatment,the levels of IgA,IgE,IgG and the number of CD3^+,CD4^+and CD8^+T lymphocytes were detected.Results The total effective rate was 96.7%in the treatment group and 83.3%in the control group.There was significant difference between the two groups(P<0.05).Before treatment,IgA and IgE in the treatment group and the control group were significantly higher than those in the normal group(P<0.05),and there was no significant difference in IgG(P>0.05);the percentage of CD3+and CD4+lymphocytes in the treatment group and the control group before treatment were significantly lower than those in the normal group(P<0.05),while the percentage of CD8+lymphocytes was significantly higher than that in the normal group(P<0.05).After treatment,the level of IgA and IgE in the treatment group and the control group decreased significantly(P<0.05);and the difference between the two groups was also significant(P<0.05);Comparison of IgG before and after treatment in the two groups showed no significant difference(P>0.05).After treatment,the percentage of CD3^+and CD4^+lymphocytes in the treatment group was significantly increased than before(P<0.05),and the percentage of CD8^+lymphocytes was significantly decreased than before(P<0.05);there was no significant difference in the control group before and after treatment.Conclusion There are significant humoral and cellular immune disorders in children with HSP.Yupingfeng Granules can effectively correct the immune disorders and have significant clinical efficacy.
作者
段炤
林智平
徐琨
邓宇虹
刘小惠
DUAN Zhao;LIN Zhiping;XU Kun(Department of Rheumatology and Immunity,Jiangxi Provincial Children's Hospital,Nanchang 330006;Department of Gastroenterology,Jiangxi Hospital of Intergrated Traditional Chinese and Western Medicine,Nanchang 33003,China)
出处
《江西医药》
CAS
2020年第10期1377-1379,1419,共4页
Jiangxi Medical Journal
基金
江西省中医药科研课题,编号20198057。
关键词
玉屏风
过敏性紫癜
疗效
免疫功能
Yupingfeng
Henoch-Schonlein purpura
clinical efficacy
Immune function
