摘要
危险比(risk ratio,RR)和风险比(hazard ratio,HR)是前瞻性研究中常用的效应指标。但在原始研究和Meta分析中描述效应量大小时不能交替使用,如何选择合适的指标并正确解读是临床研究的关键。本文总结了效应指标中危险和风险的异同点,对比RR和HR在估计方法和临床解读之间的差异,并在同一研究中比较RR和HR的区别,并提供可行的转换公式便于在Meta分析的合并中使用。
Risk ratio(RR)and hazard ratio(HR)are two common effect measures in prospective studies.When describing the magnitude of clinical effects in the original study and meta-analysis,they cannot be used interchangeably.Selecting an appropriate measures and interpreting them correctly is critical in clinical research.In this study,we summarized similarities and differences between risk and hazard,compared differences between RR and HR in estimation methods and clinical interpretation.The magnitude of RR and HR estimated from the same studies were compared,and two feasible formulas converting between RR and HR were presented for meta-analysis.
作者
黄桥
赵明娟
罗丽莎
邓通
曾宪涛
王行环
HUANG Qiao;ZHAO Mingjuan;LUO Lisha;DENG Tong;ZENG Xiantao;WANG Xinghuan(Center for Evidence-Based and Translational Medicine,Zhongnan Hospital of Wuhan University,Wuhan 430071,P.R.China;Center for Evidence-Based and Translational Medicine,Wuhan University,Wuhan 430071,P.R.China;Department of Evidence-Based Medicine and Clinical Epidemiology,The Second Clinical College,Wuhan University,Wuhan 430071,P.R.China;Department of Urology,Zhongnan Hospital of Wuhan University,Wuhan 430071,P.R.China)
出处
《中国循证医学杂志》
CSCD
北大核心
2020年第10期1221-1225,共5页
Chinese Journal of Evidence-based Medicine
基金
国家重点研发计划“科技助力经济2020”重点专项(编号:SQ2020YFF0426494)
国家重点研发计划数字诊疗装备研发重点专项(编号:2016YFC0106300)
湖北省第二届医学领军人才工程第一层次基金,武汉市卫建委新冠肺炎疫情防控应急科研专项重点项目(编号:EG20A02)。
关键词
前瞻性研究
危险比
风险比
转换
Prospective study
Risk ratio
Hazard ratio
Conversion
