摘要
[目的]探讨酸枣仁汤代茶饮联合西药治疗肝郁血虚型失眠患者的疗效。[方法]选取2017年6月至2019年6月我院住院及门诊就诊的肝郁血虚型失眠患者112例,按照随机数字表法分为两组,每组各56例。对照组行单纯西药治疗,观察组在此基础上联合酸枣仁汤代茶饮治疗,比较两组临床疗效、治疗前后中医证候评分、睡眠质量变化及不良反应发生情况。[结果]观察组临床治疗总有效率高于对照组,差异有统计学意义(P<0.01)。两组治疗1个月后入睡困难、多梦、早醒、情绪抑郁、醒后难以入睡评分均低于治疗前,差异有统计学意义(P<0.01);观察组治疗1个月后入睡困难、多梦、早醒、情绪抑郁、醒后难以入睡评分均低于对照组,差异有统计学意义(P<0.01)。两组治疗1个月后匹兹堡睡眠质量指数量表(Pittsburgh sleep quality index,PSQI)各项评分低于治疗前,差异有统计学意义(P<0.05,P<0.01);观察组治疗1个月后睡眠质量、入睡时间、睡眠时间、睡眠效率、睡眠障碍、催眠药物、日间功能障碍及总评分均低于对照组,差异有统计学意义(P<0.01)。观察组总不良反应发生率低于对照组,差异有统计学意义(P<0.01)。[结论]酸枣仁汤代茶饮联合西药治疗肝郁血虚型失眠患者可显著提高疗效,减轻临床症状,改善患者睡眠质量,降低不良反应发生率,值得推广。
[Objective]To investigate the curative effect of Suanzaoren Decoction Tea Substitute combined with western medicine on insomnia patients with liver depression and blood deficiency syndrome. [Methods]A total of 112 insomnia patients with liver depression and blood deficiency were enrolled in our hospital from June 2017 to June 2019. The patients were divided into two groups according to the random number table method,with 56 cases in each.Patients in control group were treated with western medicine alone,and observation group was treated with Suanzaoren Decoction Tea Substitute on this basis of control group. The clinical efficacy of the two groups,the traditional Chinese medicine(TCM) syndrome scores before and after treatment,the changes in sleep quality and the occurrence of adverse reactions were compared. [Results]The total effective rate of clinical treatment in observation group was higher than that in control group,and the difference was statistically significant(P<0.01). After one month of treatment,the scores of difficulty in falling asleep,dreaminess,early awakening,emotional depression and difficulty in falling asleep after waking up were lower than those before treatment(P<0.01). In observation group,after one month of treatment,the scores of difficulty in falling asleep,dreaminess,early awakening,emotional depression,and difficulty in falling asleep after waking were lower than control group,and the difference was statistically significant(P<0.01). Pittsburgh sleep quality index(PSQI) scores of the two groups after 1 month of treatment were lower than those before treatment( P<0.05,P<0.01),and the scores of quality of sleep,sleep latency,sleep time,sleep efficiency,sleep disturbance,hypnotic drugs,daytime dysfunction and total were lower in observation group than in control group after one month of treatment,and the difference was statistically significant(P<0.01). The incidence of total adverse reactions in observation group was lower than that in control group,and the difference was statistically significant(P<0.01). [Conclusion]Suanzaoren Decoction Tea Substitute combined with western medicine for treating insomnia patients with liver depression and blood deficiency can significantly improve the curative effect,alleviate clinical symptoms,improve sleep quality and reduce the incidence of adverse reactions,and the method is worthy of promotion.
作者
朱益幡
周洁
蒋建明
ZHU Yifan;ZHOU Jie;JIANG Jianming(Suzhou City Wujiang Hospital of Traditional Chi-nese Medicine,Jiangsu,Suzhou(215200),China)
出处
《浙江中医药大学学报》
CAS
2020年第10期991-994,998,共5页
Journal of Zhejiang Chinese Medical University
基金
苏州市产业技术创新(民生科技-医疗卫生应用基础研究)项目(SYSD2017046)。
关键词
酸枣仁汤
中药
代茶饮
肝郁血虚型
失眠
疗效
睡眠质量
不良反应
Suanzaoren Decoction
traditional Chinese medicine
tea substitute
liver depression and blood deficiency type
insomnia
efficacy
sleep quality
adverse reactions
