摘要
克罗恩病是慢性炎症性肠病的一种,其发病机制一直以来是医学的研究热点及难点,选择合适的动物模型用于研究该病,对发掘潜在的治疗靶点,开发新的治疗药物显得尤为重要。随着分子生物技术的发展,可用于研究克罗恩病的动物模型越发地多样化,从最初的化学诱导动物模型,到后来的自发动物模型、细胞移植动物模型,再到如今使用广泛的基因工程动物模型等,研究人员有了更多更合适的选择。本文主要概述了这些动物模的发病机制及优缺点,为基础研究提供参考。
Crohn’s disease is a chronic inflammatory bowel disease,the pathogenesis of which has long been a hotspot of medical research but remained difficult to clarify.The selection of suitable animal models for the study of Crohn’s disease is particularly important to discover potential therapeutic targets and develop new therapeutic options.As biotechnology advances,the animal models available for studying Crohn’s disease are becoming more diverse,from the original chemically induced animal models to later spontaneous animal models,cell transplantation animal models,to the widely used genetically engineered animal models available today,giving researchers more and more suitable options.This paper provides an overview of the pathogenesis and advantages and disadvantages of these animal models,providing a reference for basic research.
作者
方磊
乔立超
顾一帆
徐雪梅
杨柏霖
陈红锦
FANG Lei;QIAO Lichao;GU Yifan;XU Xuemei;YANG Bolin;CHEN Hongjin(Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210029,China)
出处
《中国实验动物学报》
CAS
CSCD
北大核心
2020年第5期688-694,共7页
Acta Laboratorium Animalis Scientia Sinica
基金
南京中医药大学中医学优势学科三期项目立项开放课题(ZYX03KF045)
国家自然科学基金面上项目(81673973)
2020年江苏省研究生实践创新计划(SJCX20_0599)。
