摘要
肝癌是全球死亡率极高的恶性肿瘤之一。本研究将不同浓度胆固醇溶液作用于肝癌Hep G2细胞。结果显示随着胆固醇浓度的增加,细胞活力逐渐减低,细胞数量逐渐减少。此外,胆固醇能够诱导Hep G2细胞发生凋亡,Western Blot结果证实为线粒体凋亡途径。
Liver cancer is one of the malignant tumors with high mortality rate in the world. In this study, different concentrations of cholesterol solution were used to treat HepG2 cells. The results showed that with the increase of cholesterol concentration, cell viability and cell number decreased gradually. In addition, cholesterol induced the apoptosis of HepG2 cells, and western blot results indicated that cholesterol-induced apoptosis involved the mitochondrial pathway.
作者
张仁文
Zhang Renwen(Jilin Institute of Chemical Technology,Jilin 132022,China)
出处
《广东化工》
CAS
2020年第17期52-53,共2页
Guangdong Chemical Industry
基金
吉林省教育厅“十三五”科技项目,编号JJKH20190823KJ。
关键词
肝癌
胆固醇
细胞增殖
细胞凋亡
liver cancer
cholesterol
cell proliferation
apoptosis
