摘要
目的探讨微小RNA-210(miR-210)、血管内皮生长因子-A(VEGF-A)与急性冠状动脉综合征经皮冠状动脉介入治疗(PCI)后心律失常的相关性。方法选取该院2019年1—12月收治的急性冠状动脉综合征患者78例,根据PCI术后有无心律失常发生将其分为AMI组(PCI术后出现心律失常)41例、非AMI组(PCI术后未出现心律失常)37例,分别检测患者PCI术治疗前后的miR-210与VEGF-A水平,以评价两项指标对PCI术后心律失常的相关性。结果AMI组患者治疗后的miR-210水平为(0.83±0.28),VEGF-A水平为(85.45±20.76)ng/L,均明显高于非AMI组,差异有统计学意义(t=9.934、13.076,P<0.001)。同时,不同Lown分级AMI组患者的miR-210水平分别为(0.42±0.09)、(0.58±0.13)、(0.69±0.19)、(0.86±0.25)、(0.97±0.29),差异有统计学意义(F=29.426,P<0.001);不同Lown分级AMI组患者的VEGF-A水平分别为(50.4±13.6)、(66.9±16.2)、(84.2±18.4)、(96.7±24.3)、(118.6±29.7)ng/L,差异有统计学意义(F=34.786,P<0.001)。结论急性冠状动脉综合征患者PCI术后发生心律失常者的miR-210与VEGF-A水平均明显高于未发生心律失常患者,并且两项指标同心律失常程度有正相关性,从而证实miR-210与VEGF-A对患者PCI术后发生心律失常有良好预测价值。
Objective To investigate the correlation between microRNA-210(miR-210), vascular endothelial growth factor-A(VEGF-A) and arrhythmia after percutaneous coronary intervention(PCI) for acute coronary syndrome.Methods A total of 78 patients with acute coronary syndromes admitted to the hospital from January to December 2019 were selected and divided into AMI group(arrhythmia after PCI) 41 cases and non-arrhythmia after PCI. In the AMI group(without arrhythmia after PCI), 37 patients were tested for miR-210 and VEGF-A levels before and after PCI to evaluate the correlation between the two indicators for arrhythmia after PCI. Results After treatment, the miR-210 level of the AMI group was(0.83±0.28) and the VEGF-A level was(85.45±20.76)ng/L, which were significantly higher than those of the non-AMI group, the difference was statistically significante(t=9.934,13.076,P<0.001). At the same time, the miR-210 levels of AMI patients with different Lown grades were(0.42 ±0.09),(0.58 ±0.13),(0.69 ±0.19),(0.86 ±0.25),(0.97 ±0.29), and the differences were statistically significant(F =29.426, P <0.001);the levels of VEGF-A in AMI groups of different Lown grades were(50.4 ±13.6),(66.9 ±16.2),(84.2 ±18.4),(96.7 ±24.3),(118.6 ±29.7)ng/L, the differences were statistically significant(F =34.786,P <0.001). Conclusion The levels of miR-210 and VEGF-A in patients with arrhythmia after PCI in patients with acute coronary syndrome are significantly higher than those in patients without arrhythmia, and the two indicators are positively correlated with the degree of arrhythmia, thus confirming that miR-210 and VEGF-A has a good predictive value for arrhythmia after PCI.
作者
郭志强
李浩平
杨秋娴
周涛龙
GUO Zhi-qiang;LI Hao-ping;YANG Qiu-xian;ZHOU Tao-long(Department of Cardiology,Nanhai Hospital,Guangdong Provincial People's Hospital,Foshan,Guangdong Province,528251 China)
出处
《系统医学》
2020年第17期13-15,共3页
Systems Medicine
基金
佛山市医学类科技攻关项目:微小RNA-145调控VEGFR-2表达对血管内皮细胞血管生成的影响及机制(2017AB000222)。
