摘要
目的:探讨固肾安胎方在子宫动脉血流异常致复发性流产应用价值。方法:选取2016年1月~2019年12月本院收治的80例因子宫动脉血流阻力异常而导致复发性流产患者作为研究对象,按照随机数字表法分为研究组(n=40)和对照组(n=40)。在常规干预治疗的基础上,对照组采用阿司匹林100 mg/d口服治疗,研究组采用阿司匹林100 mg/d+固肾安胎方1剂/d口服治疗,两组均连续治疗2个月。比较两组治疗前和治疗后凝血功能指标水平[纤维蛋白原(FIB)、凝血酶时间(TT)和凝血酶原时间(PT)],性激素指标水平[人绒毛膜促性腺激素(HCG)、雌二醇(E 2)和孕酮(P)],阴道出血、下腹坠胀痛、腰酸痛、肛门坠胀等症状改善情况,足月产、流产、早产活婴等妊娠结局情况,B超测量结果[子宫动脉血流阻力指数(RI)、子宫动脉收缩期峰值流速与子宫动脉舒张期低值流速的比值(S/D)]以及胃肠道反应、皮疹、血小板减少、嗜睡等不良反应发生状况。结果:与对照组比较,研究组治疗后HCG、E 2、P等性激素水平均升高,FIB降低,TT、PT延长,阴道出血、下腹坠胀痛、腰酸痛、肛门坠胀等症状发生率降低,良好妊娠结局发生率升高,治疗后左侧和右侧RI以及左侧和右侧S/D均降低(P<0.05)。与同组治疗前比较,两组治疗后HCG、E 2、P等性激素水平均升高,FIB降低,TT、PT延长,阴道出血、下腹坠胀痛、腰酸痛、肛门坠胀等症状发生率降低,治疗后左侧和右侧RI以及左侧和右侧S/D均降低(P<0.05)。两组胃肠道反应、皮疹、血小板减少、嗜睡等不良反应发生率无统计学差异(P>0.05)。结论:固肾安胎方应用于子宫动脉血流异常致复发性流产,可有效改善凝血功能、子宫动脉血流状况,提高性激素水平,缓解临床症状和改善妊娠结局,具有良好的疗效和安全性,值得推广应用。
Objective:To investigate the application value of Gushen Antai recipe in recurrent abortion caused by abnormal uterine arterial blood flow.Methods:From January 2016 to December 2019,80 patients with recurrent abortion due to abnormal uterine arterial blood flow resistance and admitted to the department of obstetrics and gynecology were selected as the research object.The patients were randomly divided into study group(n=40)and control group(n=40).On the basis of conventional intervention,the control group was treated with aspirin 100 mg/d orally for 2 consecutive months,and the observation group was treated with 100 mg/d aspirin and one dose of Gushen Antai recipe for 2 consecutive months.The before and after treatment coagulation function[fibrinogen(FIB),thrombin time(TT),prothrombin time(PT)]and sex hormone index levels[human chorionic gonadotropin(HCG),estradiol(E 2),progesterone(P)],vaginal bleeding,abdominal swelling pain,waist pain,anal dilatation and other symptoms improvement,full term labor,abortion,premature infant,and other pregnancy outcome,B-ultrasound measurements[ratio of uterine artery resistance index(RI)and peak systolic velocity and low diastolic velocity(S/D)],gastrointestinal reaction,rash,thrombocytopenia,lethargy and other adverse reactions were compared between the two groups.Results:Compared with those of control group,in the study group,the after treatment HCG,E 2 and P sex hormone levels were elevated,the FIB was lower,the TT and PT were shorter,the vaginal bleeding,abdominal swelling pain,waist pain,anal dilatation rate were lower,good pregnancy outcome rate was higher,the left and the right side of the RI after treatment as well as the left and the right side of the S/D were lower(P<0.05).Compared with those of the same group before treatment,HCG,E 2 and P sex hormone levels and other sex hormones of the 2 groups were increased,FIB was decreased,TT and PT were prolonged,vaginal bleeding,abdominal swelling pain,waist pain,anal dilatation rate were decreased,and left and right RI and left and right S/D were decreased after treatment(P<0.05).There was no statistically significant difference in the rate of gastrointestinal reactions,rash,thrombocytopenia,drowsiness and other adverse reactions between the two groups(P>0.05).Conclusion:The application of Gushen Antai recipe in recurrent abortion caused by abnormal uterine artery blood flow can effectively improve the coagulation function and the condition of uterine artery blood flow,improve the level of sex hormone,relieve the clinical symptoms and improve the pregnancy outcome.It has good feasibility and safety and is worth of popularizing.
作者
刘芳
王雅莉
武明莉
杨小风
张颖
娄欢
LIU Fang;WANG Ya-li;WU Ming-li;YANG Xiao-feng;ZHANG Ying;LOU Huan(Department of Obstetrics and Gynecology,Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou 450052,China)
出处
《中国合理用药探索》
CAS
2020年第10期23-28,共6页
Chinese Journal of Rational Drug Use
基金
2018年度河南省医学科技攻关计划项目(2018020801)。
关键词
固肾安胎方
子宫动脉血流异常
复发性流产
应用价值
妊娠结局
Gushen Antai recipe
abnormal uterine arterial blood flow
recurrent abortion
application value
pregnancy outcome
