摘要
肺癌是我国发病率和死亡率居第一位的恶性肿瘤,常用的治疗方式包括放疗、化疗、分子靶向药物治疗和免疫治疗,临床应用可提高肺癌患者生存率,但预后差,不良反应较多,患者生活质量不高。研究发现,复方苦参注射液具有抗肿瘤、镇痛、增强免疫等功效,主要用于减轻癌痛。复方苦参注射液联合其他治疗方式在肺癌治疗中具有抑制癌细胞转移、减毒增效、降低不良反应发生率、提高生存率、逆转多药耐药性等作用。文章对复方苦参注射液在肺癌联合治疗中的应用现状进行了总结,并对其相关的调控机制进行了梳理,以期为复方苦参注射液在肺癌后续治疗中的应用奠定基础,并为肺癌新的中医药治疗策略的开发提供一定的参考和借鉴。
Lung cancer is a malignant tumor with the highest morbidity and mortality in our country.The commonly used treatment methods include radiotherapy,chemotherapy,molecular targeted drugs therapy and immunotherapy.Although Clinical applications can improve the survival rate of lung cancer patients,the following prognosis is poor and it might cause more adverse reactions and the quality of life of patients is not high.The study found that Compound Sophora flavescens injection has anti-tumor,analgesic and immune enhancing effects,and is mainly used to relieve cancer pain.Compound Sophora flavescens injection combined with other treatment methods has the effects of inhibiting cancer cell metastasis,attenuating toxicity and enhancing efficacy,reducing the incidence of adverse reactions,improving survival rate,reversing multidrug resistance and so on.In this paper,the application status of compound Sophora flavescens injection in the combined treatment of lung cancer is summarized,and its related regulatory mechanisms are combed,so as to lay a foundation for the application of compound Sophora flavescens injection in the subsequent treatment of lung cancer,and provide some reference for the development of new traditional Chinese medicine treatment strategies for lung cancer.
作者
吴恩慧
王琪瑞
来梦茹
程汝滨
WU Enhui;WANG Qirui;LAI Mengru;CHENG Rubin(College of Pharmaceutical Science,Zhejiang Chinese Medical University,Hangzhou 310053,China)
出处
《中国民族民间医药》
2020年第20期59-63,共5页
Chinese Journal of Ethnomedicine and Ethnopharmacy
基金
浙江省自然科学基金项目(No.LY17H290010)。
关键词
复方苦参注射液
肺癌
联合治疗
研究进展
Ccompound Kushen Injection
Lung Cancer
Therapeutic Combination
Research Progress
