摘要
目的建立宁波地区健康成年人PLT及相关参数(MPV、PCT、PDW、P-LCR)的参考区间。方法选取2017年1月-2018年11月健康体检者21650例作为调查对象,对上述人群的PLT及相关参数进行检测,对检测结果进行统计分析,按x±1.96s确定参考范围;同时对不同性别、年龄组的血小板参数指标进行比较;并选取健康人群对参考区间进行验证。结果PLT及相关参数为近似正态分布,健康成人参考区间男性PLT(134×109/L^322×109/L)、MPV(8.8 fl^12.6 fl)、PCT(0.15%~0.33%)、P-LCR(16.2%~47.2%)与女性PLT(138×109/L^340×109/L)、MPV(9.0 fl^12.8 fl)、PCT(0.16%~0.35%)、P-LCR(16.9%~48.6%)之间差异有统计学意义(P<0.05);PDW(8.6%~17.3%)性别组之间差异无统计学意义(P>0.05);男性、女性PLT、PCT在不同年龄段间差异有统计学意义(P<0.05)。选取300例健康体检者对新建参考区间进行验证,PLT、MPV、PCT、PDW、P-LCR落在参考区间内分别为98.3%、99.3%、100.0%、99.7%、99.0%。结论血小板及相关参数参考区间存在性别和年龄差异,新建立的参考区间可有效地应用于临床。
Objective The reference intervals of PLT and related parameters(MPV,PCT,PDW,P-LCR)were established for healthy adults in Ningbo.Methods A total of 21650 health checkups from January 2017 to November 2018 were selected as the survey subjects.The PLT and related parameters of the above population were tested,and the test results were statistically analyzed.The reference range was x±1.96 s;meanwhile,the platelet parameter indexes of different genders and age groups were compared;and the healthy population was selected to verify the reference interval.Results PLT and related parameters are approximately normally distributed.The healthy adult reference intervals in male were PLT(134×109/L-322×109/L),MPV(8.8 fl-12.6 fl),PCT(0.15%-0.33%),P-LCR(16.2%-47.2%),that in female were PLT(138×109/L-340×109/L),MPV(9.0 fl-12.8 fl),PCT(0.16%-0.35%),P-LCR(16.9%-48.6%),and the differences between male and female were statistically significant(P<0.05).There was no statistical significance on the difference in PDW(8.6%-17.3%)between gender groups(P>0.05).There was statistical significance on the differences between male and female in PLT and PCT among different age groups(P<0.05).300 healthy subjects were selected to verify the new reference interval.PLT,MPV,PCT,PDW,and P-LCR were in the reference interval of 98.3%,99.3%,100.0%,99.7%,and 99.0%,respectively.Conclusion There are gender and age differences in the reference intervals of platelets and related parameters.The newly established reference interval can be effectively applied in clinical practice.
作者
周世平
陈兵华
秦玲
李情操
ZHOU Shi-ping;CHEN Bing-hua;QIN Ling;LI Qing-cao(Clinical Laboratory,Ningbo Medical Center(Group)Li Huili Eastern Hospital,Ningbo,Zhejiang 315040,China)
出处
《中国卫生检验杂志》
CAS
2020年第18期2267-2270,共4页
Chinese Journal of Health Laboratory Technology
基金
宁波市自然科学基金项目(2018A610402)。
关键词
血小板
相关参数
健康成人
参考区间
Platelets
Related parameters
Healthy adults
Reference interval
