摘要
目的应用Meta分析腹腔镜与传统开腹手术治疗对结肠癌患者围手术期效果及远期生存率的影响。方法本文以PubMed及万方等数据库检索2010年1月至2019年12月收录的腹腔镜与开腹手术治疗结肠癌的效果文献,进行半随机或随机对照研究。根据制定的标准严格进行文献的筛选,提取相关资料后,利用RevMan5.2软件进行Meta分析。结果共纳入11篇文献,包含901例结肠癌患者。Meta分析结果提示,腹腔镜组术中出血量更少(WMD=148.95,95%CI:97.57~200.33;Z=5.68,P<0.00001)、术后排气时间更早(WMD=1.43,95%CI:1.21~1.64;Z=12.99,P<0.00001)、术后住院时间更短(WMD=3.60,95%CI:2.92~4.28;Z=10.44,P<0.00001)、术后并发症发生率更低(OR=3.72,95%CI:2.53~5.47;Z=6.68,P<0.00001)。结论腹腔镜下结肠癌根治术能够有效改善患者围术期治疗效果,但对远期生存率无明显影响。
Objective To analyze the effect of laparoscopy and traditional laparotomy on perioperative effect and long-term survival rate of patients with colon cancer.Methods In this study,PubMed,Wanfang,and other databases were used to search the literatures on the efficacy of laparoscopy and laparotomy in the treatment of colon cancer included from January 2010 to December 2019,and semi-randomized or randomized controlled studies were conducted.The literatures were strictly screened according to the established standards,the relevant data were extracted,and then Meta analysis was conducted by RevMan5.2 software.Results A total of 11 literatures were included,including 901 patients with colon cancer.The results of Meta analysis showed that laparoscopic group had less intraoperative blood loss volume(WMD=148.95,95%CI:97.57-200.33;Z=5.68,P<0.00001),earlier postoperative exhaust time(WMD=1.43,95%CI:1.21-1.64;Z=12.99,P<0.00001),shorter postoperative hospital stay(WMD=3.60,95%CI:2.92-4.28;Z=10.44,P<0.00001),lower incidence of postoperative complications(OR=3.72,95%CI:2.53-5.47;Z=6.68,P<0.00001).Conclusion Laparoscopic radical resection of colon cancer can effectively improve the perioperative treatment effect,but has no significant impact on the long-term survival rate.
作者
刘方杰
吴兴全
李波
LIU Fangjie;WU Xingquan;LI Bo(Zhen'an County Hospital,Shangluo 711500,China)
出处
《临床医学研究与实践》
2020年第31期32-36,共5页
Clinical Research and Practice
关键词
腹腔镜下结肠癌根治术
开腹手术
META分析
围手术期
远期生存率
laparoscopic radical resection of colon cancer
laparotomy
Meta-analysis
perioperative period
long-term survival rate
