摘要
目的观察针刺艾灸八髎穴治疗隐匿期原发性卵巢功能不全(POI)不孕症对卵泡周围血流参数及妊娠率的影响。方法将75例隐匿期POI不孕症患者按照随机字母表法分为2组。对照组30例予监测卵泡、注射用绒促性素(HCG)、地屈孕酮片治疗,治疗组45例在对照组治疗基础上加针刺艾灸八髎穴治疗。比较2组注射HCG日卵泡周围血流参数[包括收缩期峰值流速(PSV)、阻力指数(RI)、搏动指数(PI)、收缩期峰值流速/舒张末期峰值流速(S/D)]及成熟卵泡平均直径,统计比较2组6个月内(自用药开始算起)临床妊娠率及自然流产率,分析PSV、PI及RI值与妊娠率的关系。结果治疗组PSV、PI高于对照组,RI低于对照组,比较差异均有统计学意义(P<0.05),2组S/D、成熟卵泡平均直径比较差异无统计学意义(P>0.05)。治疗组6个月内妊娠率[77.8%(35/45)]高于对照组[36.7%(11/30),P<0.05],自然流产率[8.6%(3/35)]低于对照组[18.2%(2/11),P<0.05]。PSV、PI与妊娠率呈正相关(P<0.05),RI与妊娠率呈负相关(P<0.05)。结论针刺艾灸八髎穴治疗隐匿期POI不孕症能够通过改善卵泡周围血流,提高卵泡质量,从而提高妊娠率。
Objective To observe the effect of acupuncture and moxibustion at Baliao points on perifollicular blood flow parameters and pregnancy rate in the treatment of primary ovarian insufficiency(POI)infertility in latent stage.Methods 75 patients with latent POI infertility were randomly divided into two groups according to the random number table method.30 cases in the control group were treated by monitoring follicles,chorionic gonadotropin(HCG)for injection,and dydrogesterone tablets.45 cases in the treatment group were treated by acupuncture and moxibustion at Baliao points on the basis of the control group.The perifollicular blood flow parameters[including peak systolic velocity(PSV),resistance index(RI),pulsatility index(PI),systolic peak velocity/end diastolic peak velocity(S/D)]and mean diameter of mature follicles were compared between the two groups on the day of HCG injection.The clinical pregnancy rate and spontaneous abortion rate of the two groups within 6 months(from the beginning of medication)were statistically compared,and the relationship between PSV,PI,RI and pregnancy rate was analyzed.Results The PSV and PI of the treatment group were higher than those of the control group,and RI was lower than that of the control group,the differences were statistically significant(P<0.05).There was no significant difference in S/D and mean follicle diameter between the two groups(P>0.05).The pregnancy rate within 6 months in the treatment group[77.8%(35/45)]was higher than that in the control group[36.7%(11/30),P<0.05],and the spontaneous abortion rate[8.6%(3/35)]was lower than that in the control group[18.2%(2/11)].The PSV,PI were positively correlated with pregnancy rate(P<0.05),RI was negatively correlated with pregnancy rate(P<0.05).Conclusion Acupuncture and moxibustion at Baliao points can improve the quality of follicles by improving the blood flow around the follicles,thereby increasing the pregnancy rate.
作者
向曦
黄晓桃
葛曼
高静
XIANG Xi;HUANG Xiaotao;GE Man(Department of Integrated Traditional Chinese and Western Medicine,Hubei Maternal and Child Health Center,Wuhan,Hubei 430070)
出处
《河北中医》
2020年第7期1075-1079,共5页
Hebei Journal of Traditional Chinese Medicine
基金
湖北省卫生健康委员会2018—2019年度中医药科研立项项目(编号:ZY2019Q027)。
关键词
原发性卵巢功能不全
穴
八髎
卵泡
妊娠率
针刺疗法
灸法
Primary ovarian insufficiency
Acupoints,Baliao
Follicle
Pregnancy rate
Acupuncture therapy
Moxibustion
