摘要
泛素结合酶也称泛素偶联酶,泛素结合酶UBCH10是泛素结合酶体系中重要的部分。UBCH10表达异常与人类泌尿系肿瘤的发生、发展密切相关,其不仅参与了肿瘤细胞的增殖、分化等调控过程,还与乳腺癌、甲状腺癌、直肠癌等多种肿瘤进展具有高度相关性。UBCH10为泌尿系肿瘤的诊断、检查提供了新方式,为患者较低不舒适性以及早发现、早治疗提供了可能。泛素化进程中UBCH10在泌尿系肿瘤的发生、发展及预后中发挥致瘤作用,但UBCH10很有可能成为泌尿系肿瘤患者的新诊疗手段,其在泌尿系肿瘤的作用机制还需要进一步研究。
Ubiquitin-conjugating enzyme is also called ubiquitin coupling enzyme.UBCH10 is an important part of ubiquitin-conjugating enzyme system.The abnormal expression of UBCH10 is closely related to the occurrence and development of human urinary system tumors,and is involved in the regulation process of tumor cell proliferation and differentiation,and is highly correlated with the progress of breast cancer,thyroid cancer,rectal cancer and other tumors.UBCH10 provides a new way for the diagnosis and examination of urinary tract tumors,with the possibility of lower discomfort,early detection and early treatment for the patients.In ubiquitination process,UBCH10 plays an oncogenic role in the occurrence,development and prognosis of urinary tract tumors,but UBCH10 may become a new diagnosis and treatment method for the patients as well.The mechanism of UBCH10 in urological tumors still needs further study.
作者
王朝
李学东
WANG Chao;LI Xuedong(Department of Urology Surgery,the Second Affiliated Hospital of Harbin Medical University,Harbin 150001,China)
出处
《医学综述》
2020年第20期4049-4053,共5页
Medical Recapitulate
基金
黑龙江省自然科学基金(H2016016)。
