摘要
目的探讨对稳定性冠心病老年患者给予不同剂量瑞舒伐他汀治疗的临床效果。方法120例稳定性冠心病老年患者,按照随机数字表法分成大剂量组和小剂量组,各60例。小剂量组给予5 mg/d的瑞舒伐他汀治疗,大剂量组给予20 mg/d的瑞舒伐他汀治疗。对比两组临床疗效、治疗前后低密度脂蛋白胆固醇水平以及不良反应发生情况。结果大剂量组的临床总有效率93.33%高于小剂量组的70.00%,差异具有统计学意义(P<0.05)。治疗后,大剂量组低密度脂蛋白胆固醇水平(2.05±0.26)μmol/L明显低于小剂量组的(2.98±0.37)μmol/L,差异具有统计学意义(P<0.05)。大剂量组不良反应发生率10.00%低于小剂量组的31.67%,差异具有统计学意义(P<0.05)。结论对稳定性冠心病老年患者行大剂量瑞舒伐他汀治疗,能够降低患者低密度脂蛋白水平和不良反应发生率,临床疗效显著。
Objective To discuss the clinical effect of different doses of rosuvastatin on elderly patients with stable coronary heart disease.Methods A total of 120 elderly patients with stable coronary heart disease were divided into high-dose group and low-dose group according to random numerical table,with 60 cases in each group.The low-dose group was given 5 mg/d rosuvastatin,and the high-dose group was given 20 mg/d rosuvastatin.The clinical efficacy,low-density lipoprotein cholesterol levels before and after treatment and occurrence of adverse reactions were compared between the two groups.Results The total clinical effective rate 93.33%of high-dose group was higher than 70.00%of low-dose group,and the difference was statistically significant(P<0.05).After treatment,low-density lipoprotein cholesterol(2.05±0.26)μmol/L of high-dose group was obviously lower than(2.98±0.37)μmol/L of low-dose group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions 10.00%of high-dose group was lower than 31.67%of low-dose group,and the difference was statistically significant(P<0.05).Conclusion High-dose rosuvastatin treatment has a significant clinical effect for elderly patients with stable coronary heart disease,which can reduce the level of low-density lipoprotein and the incidence of adverse reactions in patients.
作者
唐三华
TANG San-hua(Internal Medicine-Cardiovascular Department,Liutie Central Hospital,Liuzhou 545007,China)
出处
《中国实用医药》
2020年第30期115-117,共3页
China Practical Medicine
关键词
稳定性冠心病
瑞舒伐他汀
大剂量
小剂量
低密度脂蛋白
老年
Stable coronary heart disease
Rosuvastatin
High-dose
Low-dose
Low density lipoprotein
Elderly patients
