摘要
代谢综合征是一组以肥胖、高血糖以及血脂代谢紊乱集结发病的临床症候群,其与多种疾病的发生有关,可使糖尿病、心血管疾病、慢性肾脏疾病的发病风险升高。高糖饮食是诱发代谢综合征的重要风险因素之一,过量摄入高糖食物会引起肥胖、胰岛素抵抗、糖尿病等疾病。模式生物果蝇是研究人类代谢疾病的理想模型,本文主要介绍黑腹果蝇糖代谢生理过程以及利用其建立高糖诱导的糖脂代谢紊乱、糖尿病、高尿酸血症、心脏病相关代谢疾病模型,为揭示高糖饮食诱导的代谢疾病发病机制以及治疗靶点的发现提供新的思路。
Metabolic syndrome is a set of clinical syndromes with obesity,hyperglycemia and dyslipidemia,which is related to the onsets of various diseases and can increase the risks of diabetes,cardiovascular diseases and chronic kidney diseases.High sugar diet is one of the important risk factors for metabolic syndrome.Excessive intake of high sugar food will cause obesity,insulin resistance,diabetes and other diseases.Model organism drosophila melanogaster is an ideal model for researching human metabolic diseases.This article mainly introduced the physiological process of glucose metabolism in drosophila melanogaster,by which models of hyperglycemic-induced glucose and lipid metabolism disorder,diabetes,hyperuricemia and metabolic diseases related to heart disease glucose to provide new ideas for revealing the pathogenesis of metabolic diseases induced by high sugar diet and finding therapeutic targets.
作者
吴棋芳
何丹
吴明江
佟海滨
WU Qifang;HE Dan;WU Mingjiang;TONG Haibin(College of Life and Environmental Science,Wenzhou University,Zhejiang,Wenzhou 325000,China)
出处
《中国医药科学》
2020年第18期26-31,共6页
China Medicine And Pharmacy
基金
国家自然科学基金(41876197)。
关键词
果蝇
高糖饮食
糖代谢
代谢综合征
Drosophila
High sugar diet
Glycometabolism
Metabolic syndromes
