摘要
目的探讨雌二醇片/雌二醇地屈孕酮片在稽留流产清宫术后的临床应用效果。方法回顾性分析2018年1月~2019年12月于本院进行清宫手术的75例稽留流产患者的临床资料,采用随机数字表法将其分为对照组(n=37)与观察组(n=38)。对照组予以常规抗感染、止血等对症治疗,观察组在此基础上予以芬吗通治疗,观察两组患者的阴道流血时间、首次月经复潮时间、子宫内膜厚度、性激素[促黄体生成素(LH)、促卵泡激素(FSH)、雌二醇(E2)]水平、炎症因子[C反应蛋白(CRP)、白细胞介素-6(IL-6)]水平的变化以及并发症发生率。结果观察组的阴道流血时间、首次月经复潮时间短于对照组,子宫内膜厚度较对照组更厚,差异有统计学意义(P<0.05);两组治疗前的LH、FSH、E2比较,差异无统计学意义(P>0.05),治疗后观察组的LH、FSH、E2低于对照组,差异有统计学意义(P<0.05);两组治疗前的CRP、IL-6比较,差异无统计学意义(P>0.05),观察组治疗后的CRP、IL-6低于对照组,差异有统计学意义(P<0.05);观察组并发症发生率为5.26%,低于对照组的21.62%,差异有统计学意义(P<0.05)。结论在稽留流产清宫术后应用芬吗通,既可以缩短患者阴道流血、首次月经复潮时间,又可以改善患者的子宫内膜厚度、性激素水平与炎症因子水平,同时还能够降低术后并发症发生率,改善患者预后。
Objective To explore the clinical application effect of estradiol tablets/estradiol and dydrogesterone tablets after curettage for missed abortion.Methods The clinical data of 75 patients with missed abortion who underwent curettage in our hospital from January 2018 to December 2019 were retrospectively analyzed.They were divided into the control group(n=37)and the observation group(n=38)through random number table method.The control group was given conventional symptomatic treatment such as anti-infection treatment and hemostasis,while the observation group was administered femoston for treatment on this basis.The changes of vaginal bleeding time,time of first menstrual recurrence,endometrial thickness,sex hormone[luteinizing hormone(LH),follicle-stimulating hormone(FSH),estradiol(E2)]level and inflammatory factor[C-reactive protein(CRP),interleukin-6(IL-6)]level and the incidence of complications in the two groups of patients were observed.Results The vaginal bleeding time and the time of first menstrual recurrence in the observation group were shorter than those in the control group,and the endometrial thickness was thicker than that in the control group,with statistically significant differences(P<0.05).There was no statistically significant difference in LH,FSH and E2 between the two groups before treatment(P>0.05).After treatment,the LH,FSH and E2 in the observation group were lower than those in the control group,with statistically significant differences(P<0.05).There was no statistically significant difference in CRP and IL-6 between the two groups before treatment(P>0.05).The CRP and IL-6 in the observation group after treatment were lower than those in the control group,with statistically significant differences(P<0.05).The incidence of complications in the observation group was 5.26%,lower than the 21.62%in the control group,and the difference was statistically significant(P<0.05).Conclusion The application of femoston after curettage for missed abortion can not only shorten the vaginal bleeding time and the time of first menstrual recurrence,but also ameliorate the endometrial thickness,sex hormone level and inflammatory factor level of the patients,and meanwhile reduce the incidence of postoperative complications and improve the prognosis for the patients.
作者
仝建业
TONG Jianye(Department of Obstetrics and Gynecology,the Second Affiliated Hospital of Xuzhou Medical University,Jiangsu,Xuzhou 221006,China)
出处
《中国医药科学》
2020年第18期91-94,共4页
China Medicine And Pharmacy
关键词
芬吗通
稽留流产
清宫术
子宫内膜厚度
炎症因子
Femoston
Missed abortion
Curettage
Endometrial thickness
Inflammatory factor
