摘要
目的分析阿昔替尼致不良反应(ADR)的临床表现和特点,为其临床安全用药提供参考。方法检索PubMed、Web ofScience、中国知网数据库和万方数据库关于阿昔替尼的不良反应文献并进行分析。结果阿昔替尼致ADR的个案报道18例;年龄分布以50~70岁居多(11例,61.11%);ADR多发生在用药后180d内(13例,72.22%);阿昔替尼致ADR累及器官/系统主要以消化系统(6例,33.33%)和血液系统(6例,33.33%)为主。结论阿昔替尼引起的不良反应可累及全身多个系统,临床使用时需加强用药监测,警惕不良反应的发生。
Objective To analyze the clinical manifestations and characteristics of adverse drug reaction(ADR)induced by Axitinib in order to provide references for rational drug use.Methods PubMed,Web of Science,CNKI and Wan-fang databases were searched for ADR induced by Axitinib,and the collected literatures were further analyzed statistically.Results Eighteen ADR were indentified and included.Patients of 50 to 70 years showed the highest incidence(n=11,61.11%).ADR of axitinib frequently occurred within 180 days after medication(n=13,72.22%).Axitinib induced ADR were mainly digestive system(n=6,33.33%)and hematological system(n=6,33.33%).Conclusion The ADR induced by axitinib may involve multiple systems.Physicians and pharmacists should pay more attentions to the safety monitoring of axitinib during medication,be alert to the occurrence of ADR.
作者
代爽
孟帅
臧美彤
张洁
DAI Shuang;MENG Shuai;ZANG Mei-tong;ZHANG Jie(Department of Pharmacy,Tianjin Medical University Cancer Institute and Hospital,National Clinical Research Center for Cancer,Key Laboratory of Cancer Prevention and Therapy,Tianjin's Clinical Research Center for Cancer,Tianjin 300060,China)
出处
《现代药物与临床》
CAS
2020年第9期1903-1908,共6页
Drugs & Clinic
基金
天津市教委科研计划项目(2019KJ187)
关键词
阿昔替尼
不良反应
文献分析
消化系统
血液系统
axitinib
adverse drug reaction
literature analysis
digestive system
hematological system
