期刊文献+

急性早幼粒细胞白血病治疗后继发急性髓系白血病部分分化型一例并文献复习 被引量:5

Secondary acute myeloid leukemia with partial differentiation following treatment of acute promyelocytic leukemia: report of one case and review of literature
原文传递
导出
摘要 目的:探讨急性早幼粒细胞白血病(APL)患者缓解期间发生继发性白血病的潜在机制。方法:回顾性分析山西医科大学第二医院收治的1例妊娠合并APL患者在疾病发展不同时期的诊疗经过,结合相关文献讨论其发病机制、治疗及预后。结果:1例t(15;17)(q22;q21)的APL患者经诱导化疗后缓解期持续3年余,复发时AML1-ETO融合基因阳性,t(8;21)(q22;q22)染色体异常及NRAS基因突变,提示该患者复发为急性髓系白血病部分分化型。结论:APL患者缓解后发生继发性白血病临床比较罕见,可能与药物毒性诱导克隆改变和"劣势克隆"扩增有关。
作者 任维肖 陈秀花 任颜 夏婷 罗明 徐智芳 常建梅 王宏伟 Ren Weixiao;Chen Xiuhua;Ren Yan;Xia Ting;Luo Ming;Xu Zhifang;Chang Jianmei;Wang Hongwei(The Second Clinical Medical College of Shanxi Medical University,Taiyuan 030001,China;Institute of Hematology,the Second Hospital of Shanxi Medical University,Shanxi Key Laboratory of Molecular Diagnosis and Treatment of Blood Diseases,Taiyuan 030001,China)
出处 《白血病.淋巴瘤》 CAS 2020年第9期556-560,共5页 Journal of Leukemia & Lymphoma
基金 国家自然科学基金面上项目(81670126) 山西省自然科学基金重点项目(201801D111003)。
  • 相关文献

参考文献3

二级参考文献12

  • 1Leone G, Mele L, Pulsoni A, et al. The incidence of secondary leukemias. Haematologica,1999, 84:937-945.
  • 2Latagliata R,Petti MC, Fenu S, et al. Therapy-related myelodysplastic syndrome- acute myelogenous leukemia in patients treated for acute promyelocytic leukemia: an emerging problem. Blood, 2002,99:822-824.
  • 3Lobe I, Rigal-Huguet F, Vekhoff A, et al. Myelodysplastic syndrome after acute promyelocytic leukemia: the European APL group experience. Leukemia,2003,17 : 1600-1604.
  • 4Batzios C, Hayes LA, He SZ, et al. Secondary clonal cytogenetic abnormalities following successful treatment of acute promyelocytic leukemia. Am J Hematol,2009,84:715-719.
  • 5Metayer C, Curtis RE, Vose J, et al. Myelodysplastic syndrome and acute myeloid leukemia after autotransplantation for lymphoma: a muhicenter case-control study. Blood, 2003,101 : 4573- 4575.
  • 6Raimondi SC, Pui CH, Head DR, et al. Cytogenetically different leukemic clones at relapse of childhood acute lymphoblastic leukemia. Blood, 1993,82:576-580.
  • 7Au WY, Kumana CR, Lam CW, et al. Solid tumors subsequent to arsenic trioxide treatment for acute promyelocytic leukemia. Leuk Res, 2007, 31: 105-108.
  • 8Litzow MR, Tarima S, Perez WS, et al. Allogenetic transplantantion for therapy-related myelodysplastie syndrome and acute myeloid leukemia. Blood, 2010, 115: 1850-1857.
  • 9段衍超,张志瑢.乳腺癌化疗后继发急性早幼粒细胞白血病二例并文献复习[J].白血病.淋巴瘤,2013,22(2):122-123. 被引量:4
  • 10包维莺,胡喜梅,周水阳,柯金,范燕琴,陆翠,王恒石,朱锐锋,刘媛,范璐,肖素芳.乳腺癌化疗后继发急性早幼粒细胞白血病2例并文献复习[J].临床血液学杂志,2017,30(3):393-394. 被引量:3

共引文献9

同被引文献27

引证文献5

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部