摘要
单纯疱疹病毒Ⅰ型(HSV-1)属于疱疹病毒α亚科,在人群中广泛传播,感染机体后可建立潜伏感染并在宿主体内存活终生。病毒感染后机体的许多先天免疫被激活,同时HSV-1也进化出逃避宿主的免疫反应,其中涉及到不同的信号通路、转录因子及免疫细胞等。本文简要综述HSV-1的感染机制和病毒的逃逸机制,为今后防治药物和疫苗的研发奠定基础。
Herpes simplex virus typeⅠ(HSV-1)belongs to the herpesvirus alpha subfamily and spreads widely in the human population.After HSV-1 infection,the viruses can establish a latent infection and persist in humans for the lifetime of the host organism.A number of innate immunity of the body was activated following HSV-1 infection,while the virus evolves to evade the host immune responses,involving different signaling pathways,transcription factors and immune cells.In this paper,we reviewed the mechanism of virus infection and escape,which will lay a theoretical foundation for drug treatment and vaccine development of HSV-1.
作者
张晶晶
李琦涵
ZHANG Jing-Jing;LI Qi-Han(Institute of Medical Biology,Chinese Academy of Medical Sciences&Peking Union Medical College/Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Disease,Kunming 650118,China)
出处
《生物技术通讯》
CAS
2020年第4期478-485,共8页
Letters in Biotechnology
基金
国家自然科学基金(31670173)
中国医学科学院医学与健康科技创新工程项目(2016-I2M-1-019)。
关键词
单纯疱疹病毒Ⅰ型
天然免疫
激活
免疫逃逸
Herpes simplex virus typeⅠ(HSV-1)
innate immunity
activate
immune escape
