摘要
目的:观察银杏叶提取物(金纳多)注射液预先给药对下肢缺血再灌注所致肺损伤的保护作用,为金纳多注射液的临床应用提供参考。方法:120例单侧下肢手术患者被随机分配到A组、B组和C组,每组40例,A组在使用止血带前15 min静脉泵入金纳多注射液(用量为1 ml/kg溶于100 ml生理盐水),B组用量为2 ml/kg溶于100 ml生理盐水,C组仅给予等量生理盐水,分别于上止血带前(T 1)、松止血带后5 min(T 2)、松止血带后15 min(T 3)、松止血带后30 min(T 4)计算受试者平均动脉压(MAP)、心率(HR)、肺泡动脉血氧分压差(PA-aDO 2)和呼吸指数(RI),采用SPSS 21.0统计软件进行统计分析。结果:三组的MAP和HR均表现为随着时间的延长先降低又有一定程度升高的趋势,在T 2、T 3、T 4,MAP的差异均有统计学意义(P<0.05),A组在T 2、T 3的HR低于T 1(P<0.05),C组在T 2、T 3、T 4的HR均低于T 1,差异有统计学意义(P<0.05)。三组的PA-aDO 2和RI均表现为随着时间的延长而延长的趋势,在T 2、T 3,PA-aDO 2的差异均有统计学意义(P<0.05),在T 2、T 3,RI的差异均有统计学意义(P<0.05)。结论:金纳多注射液预先给药对下肢缺血再灌注所致肺损伤具有一定的保护作用。
Objective To observe the protective effect of Ginkgo biloba extract(Ginaton)injection on lung injury induced by lower limb ischemia-reperfusion,and to provide reference for clinical application of Ginaton injection.Method 120 patients undergoing unilateral lower extremity surgery were randomly assigned to group A,group B and group C,40 cases in each group.Ginaton extract injection(1 ml/kg dissolved in 100 ml saline)was intravenously pumped 15 minutes before tourniquet was used in group A,while 2 ml/kg dissolved in 100 ml saline in group B,and only the same amount was given in group C.The mean arterial pressure(MAP),heart rate(HR),Pulmonary Alveolar arterial oxygen partial pressure difference(PA-aDO 2)and respiratory index(RI)were calculated before the upper tourniquet(T 1),5 minutes after the tourniquet(T 2),15 minutes after the tourniquet(T 3)and 30 minutes after the tourniquet(T 4),respectively.SPSS21.0 statistical software was used for statistical analysis.Results The MAP and HR of the three groups decreased firstly and increased to a certain extent with time prolonging.The difference of MAP in T 2,T 3 and T 4 was statistically significant(P<0.05).The HR of group A in T 2 and T 3 was lower than that of group T 1(P<0.05).The HR of group C in T 2,T 3 and T 4 was lower than that of group T 1(P<0.05).PA-aDO 2 and RI in the three groups showed a trend of prolongation with time.In T 2,T 3,PA-aDO 2 had statistical significance(P<0.05),and in T 2,T 3,RI had statistical significance(P<0.05).Conclusion Ginaton injection has protective effect on lung injury induced by lower limb ischemia reperfusion.
作者
陆国能
蓝晟恺
胡春江
黄柳
张裕资
LU Guo-neng;LAN Sheng-kai;HU Chun-jiang(Laibin Hospital of traditional Chinese Medicne,Laibin 546100,China)
出处
《吉林医学》
CAS
2020年第11期2607-2610,共4页
Jilin Medical Journal
关键词
金纳多
缺血再灌注
肺损伤
Ginaton
Ischemia-reperfusion
Lung injury
